A NEW ROUTE TO TRANS-2,5-DIALKYLPYRROLIDINES

被引：4

作者：

DUMAS, F

DANGELO, J

机构：

[1] Laboratoire de Chimie Organique, Faculté de Pharmacie, 92290 Châtenay-Malabry, 5, rue Jean-Baptiste Clément

来源：

TETRAHEDRON LETTERS | 1992年 / 33卷 / 15期

关键词：

INTRAMOLECULAR MICHAEL-TYPE N-HETEROCYCLIZATION; TRANS-2,5-DIALKYLPYRROLIDINES; ANT VENOMS;

D O I：

10.1016/0040-4039(92)88125-O

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Benzylic amines 8 react with ketoenoates 7 yielding, after reduction of the primary adducts, 2,5-dialkylpyrrolidines 9 (trans isomer predominating). This reaction has been applied to the synthesis of trans 2-heptyl-5-ethylpyrrolidine, a component of the venom of fire ant (Solenopsis punctaticeps).

引用

页码：2005 / 2008

页数：4

共 17 条

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