MARKED ENHANCEMENT OF ACYL-COA SYNTHETASE-ACTIVITY AND MESSENGER-RNA, PARALLELED TO LIPOPROTEIN-LIPASE MESSENGER-RNA, IN ADIPOSE TISSUES OF ZUCKER OBESE RATS (FA/FA)

被引：44

作者：

SHIMOMURA, I ^{[1
]}

TOKUNAGA, K ^{[1
]}

JIAO, S ^{[1
]}

FUNAHASHI, T ^{[1
]}

KENO, Y ^{[1
]}

KOBATAKE, T ^{[1
]}

KOTANI, K ^{[1
]}

SUZUKI, H ^{[1
]}

YAMAMOTO, T ^{[1
]}

TARUI, S ^{[1
]}

MATSUZAWA, Y ^{[1
]}

机构：

[1] TOHOKU UNIV,GENE RES CTR,SENDAI,MIYAGI 980,JAPAN

来源：

BIOCHIMICA ET BIOPHYSICA ACTA | 1992年 / 1124卷 / 02期

关键词：

ACYL-COA SYNTHETASE; LIPOPROTEIN LIPASE; MESSENGER RNA; MESENTERIC FAT; SUBCUTANEOUS FAT; (ZUCKER FATTY RAT);

D O I：

10.1016/0005-2760(92)90086-B

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

To clarify the role of acyl-CoA synthetase in development of obesity, the mRNA levels and activities were studied in Zucker fatty rats (fa/fa). In Zucker fatty rats compared with their lean littermates, marked enhancement of ACS were observed in adipose tissues. Obese/lean rats ratio of ACS activity and mRNA in abdominal subcutaneous fat (3.3- and 3.9-fold, respectively) were greater than in mesenteric fat (2.0- and 2.2-fold). The enhancement of ACS activity and mRNA in the liver of fatty rats (1.2- and 1.8-fold) were less than those in the adipose tissues. There were no enhancement of ACS activities and mRNA levels in heart tissue of the obese rats. LPL mRNA levels were also enhanced in adipose tissue of fatty rats and obese/lean ratio of LPL mRNA was also higher in abdominal subcutaneous fat than mesenteric fat (6.2- vs 3.1-fold). The larger obese/lean rats ratio of LPL and ACS parameters in abdominal subcutaneous fat than mesenteric fat may be related to the observation that the increase of subcutaneous fat weight was larger than that of mesenteric fat weight in fatty rats (21.1- vs 4.9-fold). Integrated enhancement of LPL and ACS gene expression in adipose tissue may play an important role in the development of obesity.

引用

页码：112 / 118

页数：7

共 43 条

[1] FATTY ACID ACTIVATION AND ACYL TRANSFER IN ORGANS FROM RATS IN DIFFERENT NUTRITIONAL STATES [J].