COMPARISON OF THE MEASUREMENT OF SERUM COTININE LEVELS BY GAS-CHROMATOGRAPHY AND RADIOIMMUNOASSAY

被引：13

作者：

ANDERSON, IGM ^{[1
]}

PROCTOR, CJ ^{[1
]}

HUSAGER, L ^{[1
]}

机构：

[1] MEDILAB AS,DK-1304 COPENHAGEN,DENMARK

来源：

ANALYST | 1991年 / 116卷 / 07期

关键词：

RADIOIMMUNOASSAY; GAS CHROMATOGRAPHY CROSS-CHECKS; COTININE; HUMAN SERUM; ENVIRONMENTAL TOBACCO SMOKE;

D O I：

10.1039/an9911600691

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Standard continine solutions, controls and human serum samples containing cotinine have been measured by both radioimmunoassay (RIA) and gas chromatographic (GC) techniques. Cross-checks on standards and controls showed good agreement. However, for samples containing > 50 ng ml-1 of cotinine, RIA gave results on average 60% higher than GC. Determinations by using RIA and GC on samples containing < 7 ng ml-1 of cotinine gave no significant correlation. The importance of the age of the serum sample has been investigated, and it is suggested that the age may affect the determination when dealing with low levels of cotinine.

引用

页码：691 / 693

页数：3

共 19 条

[1]

[Anonymous], COMMUNICATION

[2] SMOKERS OF LOW-YIELD CIGARETTES DO NOT CONSUME LESS NICOTINE [J].