NORADRENALINE RELEASE FROM PERMEABILIZED SYNAPTOSOMES IS INHIBITED BY THE LIGHT CHAIN OF TETANUS TOXIN

被引：20

作者：

STECHER, B

HENS, JJH

WELLER, U

GRATZL, M

GISPEN, WH

DEGRAAN, PNE

机构：

[1] RUDOLF MAGNUS INST PHARMACOL,DIV MOL NEUROBIOL,3584 CH UTRECHT,NETHERLANDS

[2] INST MOLEC BIOL & MED BIOTECHNOL,3584 CH UTRECHT,NETHERLANDS

[3] UNIV MAINZ,INST MED MIKROBIOL,W-6500 MAINZ,GERMANY

来源：

FEBS LETTERS | 1992年 / 312卷 / 2-3期

关键词：

TETANUS TOXIN; STREPTOLYSIN-O; PERMEABILIZATION; EXOCYTOSIS; SYNAPTOSOME;

D O I：

10.1016/0014-5793(92)80933-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Noradrenaline release from rat brain cortical synaptosomes permeabilized with streptolysin 0 can be triggered by muM concentrations of free Ca2+. This process was inhibited within minutes by tetanus toxin and its isolated light chain, but not by its heavy chain. The data demonstrate that the effect of tetanus toxin on NA release from purified synaptosomes is caused by the intraterminal action of its light chain.

引用

收藏

页码：192 / 194

页数：3

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