EFFECT OF TESTOSTERONE ON BONE IN HYPOGONADAL MALES

被引：29

作者：

ISAIA, G ^{[1
]}

MUSSETTA, M ^{[1
]}

PECCHIO, F ^{[1
]}

SCIOLLA, A ^{[1
]}

DISTEFANO, M ^{[1
]}

MOLINATTI, GM ^{[1
]}

机构：

[1] OSPED SAN GIOVANNI BELLINZONA,BALDI & RIBERI LABS,TURIN,ITALY

来源：

MATURITAS | 1992年 / 15卷 / 01期

关键词：

MALE HYPOGONADISM; BONE MINERAL CONTENT; CALCITONIN; TESTOSTERONE; BONE TISSUE;

D O I：

10.1016/0378-5122(92)90061-8

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Bone mineral content (BMC) and testosterone levels were evaluated and compared in 10 hypogonadal males and 10 normal, age-matched controls. In 6 of the subjects an investigation was also carried out into the effects of testosterone administration on lumbar BMC, calcitonin (CT) response to hypercalcaemia, osteocalcin (BGP) and the fasting urinary calcium/creatinine and hydroxyproline/creatinine ratios. Our results confirm that male hypogonadism is characterized by a low BMC and that testosterone administration is able to improve this parameter and to increase both basal BGP and CT response to hypercalcaemia. Testosterone therefore probably acts on bone tissue through both a direct action on osteoblast cells and an improvement in CT secretion.

引用

页码：47 / 51

页数：5

共 11 条

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