EVIDENCE FOR A ROLE OF PROTEIN-KINASE-C ZETA-SUBSPECIES IN MATURATION OF XENOPUS-LAEVIS OOCYTES

被引：160

作者：

DOMINGUEZ, I ^{[1
]}

DIAZMECO, MT ^{[1
]}

MUNICIO, MM ^{[1
]}

BERRA, E ^{[1
]}

DEHERREROS, AG ^{[1
]}

CORNET, ME ^{[1
]}

SANZ, L ^{[1
]}

MOSCAT, J ^{[1
]}

机构：

[1] UNIV AUTONOMA MADRID,CSIC,CTR BIOL MOLEC,CANTO BLANCO,E-28049 MADRID,SPAIN

来源：

MOLECULAR AND CELLULAR BIOLOGY | 1992年 / 12卷 / 09期

关键词：

D O I：

10.1128/MCB.12.9.3776

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A number of studies have demonstrated the activation of phospholipase C-mediated hydrolysis of phosphatidylcholine (PC-PLC) both by growth factors and by the product of the ras oncogene, p21ras. Evidence has been presented indicating that the stimulation of this phospholipid degradative pathway is sufficient to activate mitogenesis in fibroblasts as well as that it is sufficient and necessary for induction of maturation in Xenopus laevis oocytes. However, the mechanism whereby PC-PLC transduces mitogenic signals triggered by growth factors or oncogenes remains to be elucidated. In this study, data are presented that show the involvement of protein kinase C zeta-subspecies in the channelling of the mitogenic signal activated by insulin-p21rac-PC-PLC in Xenopus oocytes as well as the lack of a critical role of protein kinase C isotypes-alpha, beta, gamma, delta, and epsilon in these pathways.

引用

页码：3776 / 3783

页数：8

共 33 条

[1] ACTIVATORS OF PROTEIN KINASE-C TRIGGER CORTICAL GRANULE EXOCYTOSIS, CORTICAL CONTRACTION, AND CLEAVAGE FURROW FORMATION IN XENOPUS-LAEVIS OOCYTES AND EGGS [J].

BEMENT, WM ;

CAPCO, DG .

JOURNAL OF CELL BIOLOGY, 1989, 108 (03) :885-892

[2] INOSITOL TRISPHOSPHATE AND DIACYLGLYCEROL - 2 INTERACTING 2ND MESSENGERS [J].

BERRIDGE, MJ .

ANNUAL REVIEW OF BIOCHEMISTRY, 1987, 56 :159-193

[3] RAPID FORMATION OF DIACYLGLYCEROL FROM PHOSPHATIDYLCHOLINE - A PATHWAY FOR GENERATION OF A 2ND MESSENGER [J].

BESTERMAN, JM ;

DURONIO, V ;

CUATRECASAS, P .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1986, 83 (18) :6785-6789

[4] RAS PROTEINS CAN INDUCE MEIOSIS IN XENOPUS OOCYTES [J].

BIRCHMEIER, C ;

BROEK, D ;

WIGLER, M .

CELL, 1985, 43 (03) :615-621

[5]

DEHERREROS AG, 1991, J BIOL CHEM, V266, P6825

[6] EVIDENCE FOR A ROLE OF PHOSPHATIDYLCHOLINE-HYDROLYZING PHOSPHOLIPASE-C IN THE REGULATION OF PROTEIN-KINASE-C BY RAS AND SRC ONCOGENES [J].

DIAZLAVIADA, I ;

LARRODERA, P ;

DIAZMECO, MT ;

CORNET, ME ;

GUDDAL, PH ;

JOHANSEN, T ;

MOSCAT, J .

EMBO JOURNAL, 1990, 9 (12) :3907-3912

[7]

DIAZMECO MT, 1991, J BIOL CHEM, V266, P22597

[8]

DIAZMECO MT, UNPUB

[9] ROLE OF GTPASE ACTIVATING PROTEIN IN MITOGENIC SIGNALING THROUGH PHOSPHATIDYLCHOLINE-HYDROLYZING PHOSPHOLIPASE-C [J].

DOMINGUEZ, I ;

MARSHALL, MS ;

GIBBS, JB ;

DEHERREROS, AG ;

CORNET, ME ;

GRAZIANI, G ;

DIAZMECO, MT ;

JOHANSEN, T ;

MCCORMICK, F ;

MOSCAT, J .

EMBO JOURNAL, 1991, 10 (11) :3215-3220

[10]

EXTON JH, 1990, J BIOL CHEM, V265, P1

← 1 2 3 4 →