AN ISOBOLOGRAPHIC ANALYSIS OF THE HYPNOTIC EFFECTS OF COMBINATIONS OF DEXMEDETOMIDINE WITH FENTANYL OR DIAZEPAM IN RATS

被引：8

作者：

HORVATH, G ^{[1
]}

SZIKSZAY, M ^{[1
]}

RUBICSEK, G ^{[1
]}

BENEDEK, G ^{[1
]}

机构：

[1] ALBERT SZENT GYORGYI MED UNIV,DIV HLTH VISITORS,H-6720 SZEGED,HUNGARY

来源：

LIFE SCIENCES | 1992年 / 50卷 / 23期

关键词：

D O I：

10.1016/0024-3205(92)90071-V

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The effects of the combinations of dexmedetomidine-fentanyl and dexmedetomidine-diazepam on the righting reflex were studied in rats. The doses that block the righting reflex for the agents given alone and for their combinations were determined with a probit procedure and compared with an isobolographic analysis. The interactions between dexmedetomidine and fentanyl or diazepam were found to be synergistic. In the dexmedetomidine-diazepam combination studies, less than one-fourth of the single drug dose (for each of two agents) was needed to produce the required effect. These data confirm synergistic interactions between dexmedetomidine and fentanyl or diazepam in producing hypnotic-anesthetic action.

引用

页码：PL215 / PL220

页数：6

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