EFFECTS OF LIGHT-BEAM SIZE ON FLUENCE DISTRIBUTION AND DEPTH OF NECROSIS IN SUPERFICIALLY APPLIED PHOTODYNAMIC THERAPY OF NORMAL RAT-BRAIN

被引:15
作者
CHEN, Q
WILSON, BC
DERESKI, MO
PATTERSON, MS
CHOPP, M
HETZEL, FW
机构
[1] HAMILTON REG CANC CTR,DEPT MED PHYS,HAMILTON,ONTARIO,CANADA
[2] OAKLAND UNIV,DEPT PHYS,ROCHESTER,MI 48309
[3] MCMASTER UNIV,HAMILTON L8S 4L8,ONTARIO,CANADA
[4] HENRY FORD HOSP,DEPT NEUROL,DETROIT,MI 48202
关键词
D O I
10.1111/j.1751-1097.1992.tb02174.x
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The light fluence distributions of 632.8 nm light incident on the exposed surface of normal rat brain in vivo have been measured using an interstitial, stereotactically-mounted optical fiber detector with isotropic response. The dependence of the relative fluence rate on depth and the spatial distribution of fluence were compared for incident beam diameters of 3 and 5 mm. The fluence rate at depth of 1-6 mm along the optical axis within the brain tissue was approximately 70% greater for a 5 mm diameter beam than for a 3 mm beam, at the same incident fluence rate, although the plots of the relative fluence rate vs depth were parallel over the depth range 1-6 min. The depths of necrosis resulting from photodynamic treatment of brain tissue using the photosensitizer Photofrin and irradiation by 632 nm light with 3 and 5 mm incident beams were also measured. The observed difference in necrosis depths was consistent with the measured difference in fluence. The importance of beam size in photodynamic treatment with small diameter incident light fields is discussed.
引用
收藏
页码:379 / 384
页数:6
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