GLYCINE SENSORS IN THE HEPATOPORTAL SYSTEM AND THEIR REFLEX EFFECTS ON PANCREATIC EFFERENTS IN THE RAT

被引:9
作者
SAITOU, S
TANAKA, K
INOUE, S
TAKAMURA, Y
NIIJIMA, A
机构
[1] NIIGATA UNIV,SCH MED,DEPT PHYSIOL,757 ASAHIMACHI DORI,NIIGATA 951,JAPAN
[2] YOKOHAMA CITY UNIV,SCH MED,DEPT INTERNAL MED 3,YOKOHAMA,KANAGAWA 232,JAPAN
关键词
VAGAL HEPATIC AFFERENT; VAGAL PANCREATIC EFFERENT; GLYCINE;
D O I
10.1016/0304-3940(93)90335-I
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
We earlier reported the existence of vagal arginine, alanine, and leucine sensors in the liver which modulate amino acid-induced pancreatic hormone secretion. To determine the possible existence of glycine sensors in the liver and their reflex effects, afferent discharges from the hepatic branch and efferent discharges from the pancreatic branch of the vagus nerve were recorded. Intraportal administration of 0. 1, 1, and 10 MM Of L-glycine solution (0.1 ml) depressed the afferent discharge rate of the hepatic branch of the nerve in a dose-dependent manner, and increased the efferent discharge rate of the pancreatic vagal branch. The results suggest the existence of glycine sensors in the hepato-portal system that exert reflex regulation on the pancreatic vagus nerve activity.
引用
收藏
页码:12 / 14
页数:3
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