RECOGNITION OF VIRUSES AND XENOGENEIC PROTEINS BY THE BLUE-CRAB, CALLINECTES-SAPIDUS - HUMORAL RECEPTOR FOR BACTERIOPHAGE-T2

被引：16

作者：

MCCUMBER, LJ

HOFFMANN, EM

CLEM, LW

机构：

[1] UNIV FLORIDA,COLL MED,WHITNEY MARINE LAB,GAINESVILLE,FL 32610

[2] UNIV FLORIDA,COLL MED,DEPT IMMUNOL & MED MICROBIOL,GAINESVILLE,FL 32610

来源：

JOURNAL OF INVERTEBRATE PATHOLOGY | 1979年 / 33卷 / 01期

基金：

美国国家卫生研究院; 美国国家科学基金会;

关键词：

blue crab; Callinectes sapidus; electrophoresis; polyacrylamide gel; hemagglutionation; serum; crab; T[!sub]2[!/sub; T[!sub]3[!/sub; T[!sub]4[!/sub; T[!sub]7[!/sub; bacteriophages;

D O I：

10.1016/0022-2011(79)90124-1

中图分类号：

Q95 [动物学];

学科分类号：

071002 ;

摘要：

The blue crab, Callinectes sapidus, was found to possess a naturally occurring humoral factor which neutralizes T2 bacteriophage in a relatively specific fashion. The molecule responsible for this neutralization was isolated from crab plasma and shown to be distinct from hemocyanin and the hemagglutinin for mouse erythrocytes. The neutralizing activity of this molecule was lost on exposure to denaturing solvents but was resistant to mild heat or EDTA. This molecule appears to be a polymer (6-13 S) of noncovalently linked subunits each with a molecular weight of ∼80,000. The actual function of this molecule in the blue crab is unknown but based upon structural considerations it seems unlikely that it represents any evolutionary relationship to immunoglobulin. © 1979.

引用

页码：1 / 9

页数：9

共 23 条

[1]

ACTON RT, 1968, BIOCH PHYSL, V24, P149

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