MODELING ANALYSIS OF AN INTERCALATED-SPIRAL ALTERNATE-DEAD-ENDED HOLLOW FIBER BIOREACTOR FOR MAMMALIAN-CELL CULTURES

被引：14

作者：

BROTHERTON, JD ^{[1
]}

CHAU, PC ^{[1
]}

机构：

[1] UNIV CALIF SAN DIEGO,DEPT APPL MECH & ENGN SCI CHEM ENGN,LA JOLLA,CA 92093

来源：

BIOTECHNOLOGY AND BIOENGINEERING | 1990年 / 35卷 / 04期

关键词：

D O I：

10.1002/bit.260350406

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The model analysis of a bioreactor with two intercalated‐spiral sets of hollow fibers with alternated dead ends is presented. Design equations are derived based on a model with two jumped fibers and an approximation of the fluid mechanics with a small fiber radius‐to‐length ratio. The performance of the bioreactor is simulated with and without cell growth utilizing a segregated radial flow model in the extracapillary space. The pressure modulus, the wall Peclet number, the Thiele modulus, and the Monod constant are used as model parameters. The results can be used to assess the proper choice of fiber permeability, fiber length, fiber spacing, and flow velocity. Copyright © 1990 John Wiley & Sons, Inc.

引用

页码：375 / 394

页数：20

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