SIGNAL TRANSDUCTION DURING C-ELEGANS VULVAR INDUCTION

被引：80

作者：

STERNBERG, PW ^{[1
]}

HORVITZ, HR ^{[1
]}

机构：

[1] MIT,HOWARD HUGHES MED INST,DEPT BIOL,CAMBRIDGE,MA 02139

来源：

TRENDS IN GENETICS | 1991年 / 7卷 / 11-12期

关键词：

D O I：

10.1016/0168-9525(91)90257-Q

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Nematode proteins related to the human epidermal growth factor receptor and Ras proteins act in a common pathway to control cell fates in response to an inductive signal. Analysis of these gene products during C. elegans vulval induction allows detailed study of their function in the context of a developing organism.

引用

页码：366 / 371

页数：6

共 37 条

[1]

AROIAN RV, 1991, GENETICS, V128, P251

[2] THE LET-23 GENE NECESSARY FOR CAENORHABDITIS-ELEGANS VULVAR INDUCTION ENCODES A TYROSINE KINASE OF THE EGF RECEPTOR SUBFAMILY [J].

AROIAN, RV ;

KOGA, M ;

MENDEL, JE ;

OHSHIMA, Y ;

STERNBERG, PW .

NATURE, 1990, 348 (6303) :693-699

[3] RAS GENES [J].

BARBACID, M .

ANNUAL REVIEW OF BIOCHEMISTRY, 1987, 56 :779-827

[4] CAENORHABDITIS-ELEGANS RAS GENE LET-60 ACTS AS A SWITCH IN THE PATHWAY OF VULVAR INDUCTION [J].

BEITEL, GJ ;

CLARK, SG ;

HORVITZ, HR .

NATURE, 1990, 348 (6301) :503-509

[5]

BOURNE HR, 1991, NATURE, V349, P117, DOI 10.1038/349117a0

[6] THE GTPASE SUPERFAMILY - A CONSERVED SWITCH FOR DIVERSE CELL FUNCTIONS [J].

BOURNE, HR ;

SANDERS, DA ;

MCCORMICK, F .

NATURE, 1990, 348 (6297) :125-132

[7]

CLARK DV, 1988, GENETICS, V119, P345

[8] INHIBITION OF NIH-3T3 CELL-PROLIFERATION BY A MUTANT RAS PROTEIN WITH PREFERENTIAL AFFINITY FOR GDP [J].

FEIG, LA ;

COOPER, GM .

MOLECULAR AND CELLULAR BIOLOGY, 1988, 8 (08) :3235-3243

[9]

FERGUSON EL, 1989, GENETICS, V123, P109

[10] A GENETIC PATHWAY FOR THE SPECIFICATION OF THE VULVAR CELL LINEAGES OF CAENORHABDITIS-ELEGANS [J].

FERGUSON, EL ;

STERNBERG, PW ;

HORVITZ, HR .

NATURE, 1987, 326 (6110) :259-267

← 1 2 3 4 →