EFFECTS OF DEXAMETHASONE ON THE HYPOTHALAMIC-PITUITARY-ADRENAL AXIS IN PRETERM INFANTS

被引：45

作者：

RIZVI, ZB

ANIOL, HS

MYERS, TF

ZELLER, WP

FISHER, SG

ANDERSON, CL

机构：

[1] LOYOLA UNIV, MED CTR, DEPT ENDOCRINOL, MAYWOOD, IL 60153 USA

[2] LOYOLA UNIV, MED CTR, NEONATOL SECT, MAYWOOD, IL 60153 USA

[3] EDWARD HINES VET ADM MED CTR, HINES, IL USA

来源：

JOURNAL OF PEDIATRICS | 1992年 / 120卷 / 06期

关键词：

D O I：

10.1016/S0022-3476(05)81971-7

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

The effects of dexamethasone therapy on the hypothalamic-pituitary-adrenal axis were tested in 10 premature infants with bronchopulmonary dysplasia by means of the corticotropin-releasing hormone stimulation test before therapy and on the seventh day of therapy. Adrenocorticotropic hormone and cortisol levels were determined by radioimmunoassay. There was significant suppression of the hypothalamic-pituitary-adrenal axis after 7 days of a currently used dexamethasone treatment regimen. A site of suppression was located at the level of the pituitary gland.

引用

页码：961 / 965

页数：5

共 17 条

[1]

ALKALAY AL, 1990, PEDIATRICS, V86, P204

[2]

AVERY GB, 1985, PEDIATRICS, V75, P106

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