EFFECTS OF TYPICAL AND ATYPICAL NEUROLEPTICS ON FOS PROTEIN EXPRESSION IN THE RAT FOREBRAIN

被引：85

作者：

FINKJENSEN, A

KRISTENSEN, P

机构：

[1] NOVO NORDISK AS,DIV PHARMACEUT,DEPT PATHOL,DK-2760 MALOV,DENMARK

[2] NOVO NORDISK AS,DIV PHARMACEUT,DEPT HISTOCHEM,DK-2760 MALOV,DENMARK

来源：

NEUROSCIENCE LETTERS | 1994年 / 182卷 / 01期

关键词：

FOS PROTEIN; PREFRONTAL CORTEX; DORSOLATERAL STRIATUM; NUCLEUS ACCUMBENS; NEUROLEPTICS; EXTRAPYRAMIDAL SIDE-EFFECT;

D O I：

10.1016/0304-3940(94)90220-8

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The effect of the atypical neuroleptics clozapine and risperidone, the potential atypical neuroleptics sertindole and NNC 22-0031 as well as the prototypical neuroleptic haloperidol on Fos protein expression in the rat forebrain was examined by use of immunohistochemistry. Fos protein expression in the limbic medial prefrontal cortex (PFC) relative to Fos protein expression in the non-limbic dorsolateral striatum (DLSt) was more pronounced for the atypical and potential atypical neuroleptics than observed with the prototypical neuroleptic, indicating that atypical and prototypical neuroleptics can be differentiated on the basis of their ability to induce Fos protein in these regions.

引用

页码：115 / 118

页数：4

共 13 条

[1]

ARNT J, 1982, ACTA PHARMACOL TOX, V51, P321

[2] REGIONALLY SPECIFIC EFFECTS OF ATYPICAL ANTIPSYCHOTIC-DRUGS ON STRIATAL FOS EXPRESSION - THE NUCLEUS-ACCUMBENS SHELL AS A LOCUS OF ANTIPSYCHOTIC ACTION [J].