AGING AND BLOOD-PRESSURE REGULATION - DOSE-RESPONSE RELATIONSHIPS FOR ANGIOTENSIN, BLOOD-PRESSURE, ATRIAL-NATRIURETIC-PEPTIDE AND ALDOSTERONE IN NORMAL SUBJECTS OF VARYING AGES

被引：2

作者：

FINN, WL ^{[1
]}

TUNNY, TJ ^{[1
]}

KLEMM, SA ^{[1
]}

RYAN, SJ ^{[1
]}

GORDON, RD ^{[1
]}

机构：

[1] UNIV QUEENSLAND,GREENSLOPES HOSP,DEPT MED,ENDOCRINE HYPERTENS RES UNIT,BRISBANE,QLD 4120,AUSTRALIA

来源：

CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY | 1993年 / 20卷 / 05期

关键词：

AGE; ALDOSTERONE; ANGIOTENSIN-II; ATRIAL NATRIURETIC PEPTIDE; BLOOD PRESSURE REGULATION; DOSE RESPONSE; HUMAN; MEAN ARTERIAL PRESSURE;

D O I：

10.1111/j.1440-1681.1993.tb01714.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1. Infusion of increasing doses of angiotensin II (AII) in normal subjects sequentially increased blood pressure, aldosterone and atrial natriuretic peptide (ANP) levels. 2. The slope of ANP response to AII was positively correlated with basal ANP and with the slope of blood pressure response to AII (pressor slope) but not with age. 3. This is consistent with the response of ANP to AII being mediated partly by the rise in blood pressure, independent of ageing. 4. As expected in a selected normotensive population, there was no correlation between basal blood pressure and age, but pressor slope was positively correlated with age. 5. Thus, dose-response relationships may be an index of age-induced alterations in pressure regulatory mechanisms.

引用

页码：392 / 394

页数：3

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