A COMPARISON OF IMMUNOGLOBULIN-G CONTAINING HIGH-MOLECULAR-WEIGHT COMPLEXES ISOLATED FROM CHILDREN WITH JUVENILE RHEUMATOID-ARTHRITIS AND CONGENITAL HUMAN-IMMUNODEFICIENCY-VIRUS INFECTION

被引：11

作者：

JARVIS, JN ^{[1
]}

IOBIDZE, M ^{[1
]}

TAYLOR, H ^{[1
]}

DEJONGE, J ^{[1
]}

CHANG, S ^{[1
]}

机构：

[1] CHILDRENS HOSP MICHIGAN,DETROIT,MI 48201

来源：

PEDIATRIC RESEARCH | 1993年 / 34卷 / 06期

关键词：

D O I：

10.1203/00006450-199312000-00017

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Circulating immune complexes have been described in both juvenile rheumatoid arthritis and in AIDS. We isolated high-molecular-weight complexes from plasma of children with juvenile rheumatoid arthritis and congenital human immunodeficiency virus infection by sequential gel filtration followed by affinity chromatography on protein A-Sepharose. We demonstrate that 1) mixed IgG-, IgM-, and IgA-bearing immune complexes can be found in both juvenile rheumatoid arthritis and congenital human immunodeficiency virus infection and 2) complexes isolated via affinity chromatography on protein A-Sepharose do not have detectable C4 but activate the classic complement pathway in vitro.

引用

页码：781 / 784

页数：4

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