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DEVELOPMENTAL-CHANGES IN THE EFFECTS OF METABOTROPIC GLUTAMATE-RECEPTOR ANTAGONISTS ON CA1 LONG-TERM POTENTIATION IN RAT HIPPOCAMPAL SLICES

被引：31
作者：
IZUMI, Y [1 ]
ZORUMSKI, CF [1 ]
机构：
[1] WASHINGTON UNIV,SCH MED,DEPT NEUROBIOL,ST LOUIS,MO 63110
来源：
NEUROSCIENCE LETTERS | 1994年 / 176卷 / 01期
关键词：
HIPPOCAMPUS; LONG-TERM POTENTIATION; 2-AMINO-3-PHOSPHONOPROPIONATE; 2-AMINO-4-PHOSPHONOBUTYRATE; (RS)-ALPHA-METHYL-4-CARBOXYPHENYLGLYCINE; METABOTROPIC GLUTAMATE RECEPTOR; DEVELOPMENT; PHOSPHOINOSITIDE HYDROLYSIS;
D O I：
10.1016/0304-3940(94)90878-8
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The effects of 100 mu M D,L-2-amino-3-phosphonopropionate (AP3), 100 mu M D,L-2-amino-4-phosphonobutyric acid (AP4), and 500 mu M (R,S)-alpha-methyl-4-carboxyphenylglycine (MCPG), inhibitors of phosphoinositide (PI) turnover mediated by metabotropic glutamate receptors (mGluRs), on the induction of long-term potentiation (LTP) were examined in the CA1 region of hippocampal slices prepared from 15, 30 and 60 day old rats. In 15 or 30 day old rats, AP3 and MCPG applied for 5 min immediately after tetanization inhibited LTP. AP4 was less effective. All inhibitors were ineffective against LTP in 60 day old rats. These data support the hypothesis that the role of metabotropic glutamate receptors in LTP induction is influenced by development.
引用
收藏
页码：89 / 92
页数：4
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