CHEMISTRY OF PHORBOL .11. CROTOPHORBOLONE-ENOLACETATE AND ACETOXYCROTOPHORBOLONE

被引：10

作者：

BARTSCH, H

HECKER, E

机构：

[1] Biochemisches Institut des Deutschen Krebsforschungszentrums, Heidelberg

来源：

ZEITSCHRIFT FUR NATURFORSCHUNG PART B-CHEMIE BIOCHEMIE BIOPHYSIK BIOLOGIE UND VERWANDTEN GEBIETE | 1969年 / B 24卷 / 01期

关键词：

D O I：

10.1515/znb-1969-0120

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Reaction of phorbol-13,20-diacetate with mesylchloride/pyridin induces a homoallyl rearrangement of the α-[acetoxycycloproyl]-carbinol group yielding crotophorbolone-enol-13,20-diacetate (7) and acetoxy-crotophorbolone-20-acetate (10). By alkali catalysed transesterification 7 may be converted to crotophorbolone (8). 7 is the 4,9-dihydroxy-13,20-diacetoxy-13,15-seco-tigliatetraene- (1,6,12,15)-one-(3) whereas 10 is the 4,9-dihydroxy-15,20-diacetoxy-13,15-tigliadiene-(1,6)-dione-(3,13), generated by an intramolecular migration of the acetyl group in 13-position. © 1969, Walter de Gruyter. Alle Rechte vorbehalten.

引用

页码：91 / &

共 29 条

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[10]

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