INVIVO TRANSLOCATION AND DOWN-REGULATION OF PROTEIN KINASE-C FOLLOWING INTRAVENTRICULAR ADMINISTRATION OF TETANUS TOXIN

被引：22

作者：

AGUILERA, J ^{[1
]}

YAVIN, E ^{[1
]}

机构：

[1] WEIZMANN INST SCI,DEPT NEUROBIOL,IL-76100 REHOVOT,ISRAEL

来源：

JOURNAL OF NEUROCHEMISTRY | 1990年 / 54卷 / 01期

关键词：

Ca[!sup]2+[!/sup]/phosphatidylserine‐dependent protein kinase C; Down‐regulation; Tetanus toxin;

D O I：

10.1111/j.1471-4159.1990.tb13319.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Abstract: A single intraventricular injection into adult rats of 100 mouse lethal doses of tetanus toxin (TeTox) produces a marked intracellular redistribution of Ca2+/phosphatidylserine (PtdSer)‐dependent protein kinase C (PKC) activity. Changes are particularly pronounced in hypothalamus, hippocampus, and spinal cord structures. Translocation of PKC from the inactive cytosolic compartment to a membrane‐bound active form is followed by a time‐dependent reduction in both total activity and enzyme protein. The down‐regulation of PKC activity in the hypothalamus is accompanied by a marked increase in a Ca2+/PtdSer‐independent kinase activity, predominantly in the cytosolic fraction. Our data identify PKC as a possible indirect target for TeTox and suggest that down‐regulation of the enzyme may provide a clue for tetanus neurotoxicity. Copyright © 1990, Wiley Blackwell. All rights reserved

引用

页码：339 / 342

页数：4

共 34 条

[1] TETANUS INTOXICATION CAUSES AN INCREMENT OF SEROTONIN IN THE CENTRAL-NERVOUS-SYSTEM [J].