APPLICATION OF DIMETHYLSULPHOXIDE(DMSO)/TRIFLUOROACETIC ACID(TFA) OXIDATION TO THE SYNTHESIS OF CYSTINE-CONTAINING PEPTIDE

被引：81

作者：

OTAKA, A ^{[1
]}

KOIDE, T ^{[1
]}

SHIDE, A ^{[1
]}

FUJII, N ^{[1
]}

机构：

[1] KYOTO UNIV,FAC PHARMACEUT SCI,SAKYO KU,KYOTO 606,JAPAN

来源：

TETRAHEDRON LETTERS | 1991年 / 32卷 / 09期

关键词：

D O I：

10.1016/S0040-4039(00)92050-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

S-protected cysteine derivatives [Cys(Trt), Cys(MBzl), Cys(Dbs), Cys(Bzh)] as well as cysteine were converted to cystine by the action of DMSO/TFA; as examples, two model peptides, oxytocin and an alpha-human calcitonin gene-related peptide (alpha-hCGRP), were prepared by this reaction.

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页码：1223 / 1226

页数：4

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