DOMINANT NEGATIVE REGULATION OF THE MOUSE ALPHA-FETOPROTEIN GENE IN ADULT LIVER

被引：127

作者：

VACHER, J

TILGHMAN, SM

机构：

[1] Howard Hughes Medical Institute, Department of Biology, Princeton University, Princeton

来源：

SCIENCE | 1990年 / 250卷 / 4988期

关键词：

D O I：

10.1126/science.1702902

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Transcription of the mouse α-fetoprotein gene is activated in the developing fetal liver and gut and repressed in both tissues shortly after birth. With germline transformation in mice, a cis-acting element was identified upstream of the transcription initiation she of the α-fetoprotein gene that was responsible for repression of the gene in adult liver. This negative element acts as a repressor in a position-dependent manner.

引用

页码：1732 / 1735

页数：4

共 33 条

[1] REGULATION OF MATING-TYPE INFORMATION IN YEAST - NEGATIVE CONTROL REQUIRING SEQUENCES BOTH 5' AND 3' TO THE REGULATED REGION
ABRAHAM, J
NASMYTH, KA
STRATHERN, JN
KLAR, AJS
HICKS, JB
[J]. JOURNAL OF MOLECULAR BIOLOGY, 1984, 176 (03) : 307 - 331
[2] AUFFRAY C, 1980, EUR J BIOCHEM, V107, P303
[3] PURIFICATION OF BIOLOGICALLY-ACTIVE GLOBIN MESSENGER-RNA BY CHROMATOGRAPHY ON OLIGOTHYMIDYLIC-ACID-CELLULOSE
AVIV, H
LEDER, P
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1972, 69 (06) : 1408 - &
[4] GENETIC-ANALYSIS OF ALPHA-FETOPROTEIN SYNTHESIS IN MICE
BELAYEW, A
TILGHMAN, SM
[J]. MOLECULAR AND CELLULAR BIOLOGY, 1982, 2 (11) : 1427 - 1435
[5] CHARACTERIZATION OF A SILENCER IN YEAST - A DNA-SEQUENCE WITH PROPERTIES OPPOSITE TO THOSE OF A TRANSCRIPTIONAL ENHANCER
BRAND, AH
BREEDEN, L
ABRAHAM, J
STERNGLANZ, R
NASMYTH, K
[J]. CELL, 1985, 41 (01) : 41 - 48
[6] POSTNATAL REPRESSION OF THE ALPHA-FETOPROTEIN GENE IS ENHANCER INDEPENDENT
CAMPER, SA
TILGHMAN, SM
[J]. GENES & DEVELOPMENT, 1989, 3 (04) : 537 - 546
[7] STRUCTURAL AND PATHOLOGICAL EFFECTS OF SYNTHESIS OF HEPATITIS-B VIRUS LARGE ENVELOPE POLYPEPTIDE IN TRANSGENIC MICE
CHISARI, FV
FILIPPI, P
BURAS, J
MCLACHLAN, A
POPPER, H
PINKERT, CA
PALMITER, RD
BRINSTER, RL
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (19) : 6909 - 6913
[8] SPATIAL REGULATION OF ZERKNULLT - A DORSAL-VENTRAL PATTERNING GENE IN DROSOPHILA
DOYLE, HJ
KRAUT, R
LEVINE, M
[J]. GENES & DEVELOPMENT, 1989, 3 (10) : 1518 - 1533
[9] THE GENE FAMILY ENCODING THE MOUSE RIBOSOMAL PROTEIN-L32 CONTAINS A UNIQUELY EXPRESSED INTRON-CONTAINING GENE AND AN UNMUTATED PROCESSED GENE
DUDOV, KP
PERRY, RP
[J]. CELL, 1984, 37 (02) : 457 - 468
[10] FELDMAN JB, 1984, J MOL BIOL, V178, P815, DOI 10.1016/0022-2836(84)90313-9

← 1 2 3 4 →