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NMDA ANTAGONISTS INTERACT WITH 5-HT-STIMULATED PHOSPHATIDYLINOSITOL METABOLISM AND IMPAIR PASSIVE-AVOIDANCE RETENTION IN THE RAT

被引：29
作者：
GANDOLFI, O
DALLOLIO, R
RONCADA, P
MONTANARO, N
机构：
[1] Institute of Pharmacology, University of Bologna, Bologna
来源：
NEUROSCIENCE LETTERS | 1990年 / 113卷 / 03期
关键词：
APV; EAA 5-HT interaction; Ketamine; Passive avoidance conditioning; Phosphoinositide metabolism;
D O I：
10.1016/0304-3940(90)90602-6
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The NMDA receptor antagonists APV (5 μg/10 μl/rat i.c.v.) or ketamine (12.5 mg/kg i.p.), administered 5 min before training, decreased the retention of a passive avoidance conditioning. In hippocampal or cortical slices of APV- and ketamine-treated rats, 5-HT-stimulated phosphoinositide metabolism was potentiated. It is suggested that excitatory amino acids could modulate the mechanism operative in signal transduction of serotonin; this interaction could play a role in memory retention. © 1990.
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页码：304 / 308
页数：5
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