RAPID ACTIVATION AND SUBSEQUENT DOWN-REGULATION OF THE HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 PROMOTER IN THE PRESENCE OF TAT - POSSIBLE MECHANISMS CONTRIBUTING TO LATENCY

被引:30
作者
DRYSDALE, CM [1 ]
PAVLAKIS, GN [1 ]
机构
[1] NCI,FREDERICK CANC RES & DEV CTR,ABL BASIC RES PROGRAM,FREDERICK,MD 21702
关键词
D O I
10.1128/JVI.65.6.3044-3051.1991
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
The mechanism of induction of gene expression of the human immunodeficiency virus type 1 long terminal repeat (LTR) by the Tat transactivator protein was studied in a cell fusion assay. Tat causes a rapid activation of both transcription from the LTR and accumulation of hybrid LTR-chloramphenicol acetyltransferase mRNAs. Approximately 4 h after induction by Tat, expression from the LTR promoter is down-regulated, resulting in a decrease in the accumulation of LTR mRNA. This down-regulation of expression occurs in the continued presence of Tat. Protein synthesis inhibitors can block this down-regulation; therefore, the postinduction repression of expression is dependent upon de novo protein synthesis. We propose that a labile cellular protein(s) is responsible for the low levels of human immunodeficiency virus type 1 expression, possibly contributing to the establishment of a latent state of viral expression.
引用
收藏
页码:3044 / 3051
页数:8
相关论文
共 64 条
  • [1] TRANS-ACTIVATOR GENE OF HUMAN T-LYMPHOTROPIC VIRUS TYPE-III (HTLV-III)
    ARYA, SK
    GUO, C
    JOSEPHS, SF
    WONGSTAAL, F
    [J]. SCIENCE, 1985, 229 (4708) : 69 - 73
  • [2] SECRETED PLACENTAL ALKALINE-PHOSPHATASE - A POWERFUL NEW QUANTITATIVE INDICATOR OF GENE-EXPRESSION IN EUKARYOTIC CELLS
    BERGER, J
    HAUBER, J
    HAUBER, R
    GEIGER, R
    CULLEN, BR
    [J]. GENE, 1988, 66 (01) : 1 - 10
  • [3] TAT TRANS-ACTIVATES THE HUMAN IMMUNODEFICIENCY VIRUS THROUGH A NASCENT RNA TARGET
    BERKHOUT, B
    SILVERMAN, RH
    JEANG, KT
    [J]. CELL, 1989, 59 (02) : 273 - 282
  • [4] HIV-1 TAT ACTIVATES PRESYNTHESIZED RNA IN THE NUCLEUS
    BRADDOCK, M
    CHAMBERS, A
    WILSON, W
    ESNOUF, MP
    ADAMS, SE
    KINGSMAN, AJ
    KINGSMAN, SM
    [J]. CELL, 1989, 58 (02) : 269 - 279
  • [5] NUMBER AND EVOLUTIONARY CONSERVATION OF ALPHA-TUBULIN AND BETA-TUBULIN AND CYTOPLASMIC BETA-ACTIN AND GAMMA-ACTIN GENES USING SPECIFIC CLONED CDNA PROBES
    CLEVELAND, DW
    LOPATA, MA
    MACDONALD, RJ
    COWAN, NJ
    RUTTER, WJ
    KIRSCHNER, MW
    [J]. CELL, 1980, 20 (01) : 95 - 105
  • [6] TRANSACTIVATION OF HUMAN-IMMUNODEFICIENCY-VIRUS OCCURS VIA A BIMODAL MECHANISM
    CULLEN, BR
    [J]. CELL, 1986, 46 (07) : 973 - 982
  • [7] CURCIO MJ, 1987, THESIS G WASHINGTON
  • [8] THE TRANSACTIVATOR GENE OF THE HUMAN T-CELL LYMPHOTROPIC VIRUS TYPE-III IS REQUIRED FOR REPLICATION
    DAYTON, AI
    SODROSKI, JG
    ROSEN, CA
    GOH, WC
    HASELTINE, WA
    [J]. CELL, 1986, 44 (06) : 941 - 947
  • [9] INVITRO ACTIVATION OF THE HIV-1 ENHANCER IN EXTRACTS FROM CELLS TREATED WITH A PHORBOL ESTER TUMOR PROMOTER
    DINTER, H
    CHIU, R
    IMAGAWA, M
    KARIN, M
    JONES, KA
    [J]. EMBO JOURNAL, 1987, 6 (13) : 4067 - 4071
  • [10] DRYSDALE CM, 1989, THESIS U MARYLAND CO