THERAPY FOR SHIGELLOSIS .2. RANDOMIZED, DOUBLE-BLIND COMPARISON OF CIPROFLOXACIN AND AMPICILLIN

被引:74
作者
BENNISH, ML
SALAM, MA
HAIDER, R
BARZA, M
机构
[1] TUFTS UNIV, NEW ENGLAND MED CTR, SCH MED, DEPT MED, BOSTON, MA 02111 USA
[2] INT CTR DIARRHOEAL DIS RES, DHAKA, BANGLADESH
关键词
D O I
10.1093/infdis/162.3.711
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Ciprofloxacin, 500 mg every 12 h, was compared with ampicillin, 500 mg every 6 h, both given for 5 days, in the treatment of 121 adult males hospitalized with severe shigellosis. Treatment was randomized and double-blinded. At the completion of treatment, there was resolution or marked improvement in symptoms in 57 (95%) of 60 ciprofloxacin-treated patients, 23 (88%) of 26 ampicillin-treated patients infected with an ampicillin-susceptible strain of Shigella, and 15 (43%) of 35 ampicillin-treated patients infected with an ampicillin-resistant strain of Shigella (ampicillin-R group) (P <.01, ciprofloxacin or ampicillin groups vs. ampicillin-R group). Bacteriologic failure was less common (P <.025) in the ciprofloxacin group (0/60) than in the ampicillin (3/26, 12%) or ampicillin-R groups (5/35, 14%). Ciprofloxacin-treated patients had a mean of 29 stools during the study, compared with 46 for ampicillin-treated patients (P =.004). Thus ciprofloxacin seems to be an effective, and perhaps superior, alternative to ampicillin in treating patients with shigellosis. © 1990, by The University of Chicago.
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页码:711 / 716
页数:6
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