PALLADIUM, PLATINUM, CADMIUM, AND MERCURY COMPLEXES WITH NEUTRAL ISOOROTIC AND 2-THIOISOOROTIC ACIDS - IR AND NMR SPECTROSCOPIES, THERMAL-BEHAVIOR AND BIOLOGICAL PROPERTIES

Seven complexes containing neutral isoorotic and 2-thioisoorotic acids, as well as thiocyanate and chloride anions as ligands, have been synthesized and characterized by means of both spectral (IR, H-1, and C-13 NMR) and thermal (TG and DSC) methods, as well as conductivity measurements. Spectral data suggest that any binding metal-ligand mode for uracil derivatives is not easy to propose. Therefore, isoorotic ligands must link through some oxygen atom. Likewise, 2-thioisoorotic acid seems to be [N,S] bonded in Pd(II) and Pt(IV) complexes, whereas for Hg(II) complex a distorted tetrahedral HgCl2S2 structure has been proposed. In the cadmium complex, the metal ion exhibits a CdCl2O2 coordination sphere. Antimicrobial activities of the complexes against Pseudomonas sp, E. coli, Proteus sp, Salmonella sp, Micrococcus sp, Staphylococcus sp, Bacillus sp and Candida sp were performed as a previous step in the study of their biological activity.