ISOLATION AND STRUCTURE ELUCIDATION OF NOVEL HYPOTENSIVE AGENTS, NIAZININ-A, NIAZININ-B, NIAZIMICIN AND NIAZIMININ-A+B FROM MORINGA-OLEIFERA - THE 1ST NATURALLY-OCCURRING THIOCARBAMATES

Novel hypotensive principles, niazinin A1, niazinin B 2, niazimicin 4 and niaziminin A and B 6 + 7, have been obtained from the ethanolic extract of the fresh leaves of Moringa oleifera, employing a bioassay-guided isolation procedure. Their structures have been elucidated through spectroscopic (including 2D NMR techniques) and chemical methods. These compounds are mustard oil glycosides which are very rare in Nature and are also the first examples of naturally occurring thiocarbamates.