SPECIFIC AND POTENT INHIBITION OF SPERMIDINE SYNTHASE BY THE TRANSITION-STATE ANALOG, "S-ADENOSYL-3-THIO-1,8-DIAMINOOCTANE

被引：74

作者：

TANG, KC ^{[1
]}

PEGG, AE ^{[1
]}

COWARD, JK ^{[1
]}

机构：

[1] PENN STATE UNIV,MILTON S HERSHEY MED CTR,DEPT PHYSIOL,HERSHEY,PA 17033

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1980年 / 96卷 / 03期

关键词：

D O I：

10.1016/0006-291X(80)90102-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

引用

页码：1371 / 1377

页数：7

共 16 条

[1]

[Anonymous], 1979, CONSUMENTENGIDS, P215

[2]

CANTONI GL, 1979, TRANSMETHYLATION, P155

[3] POLYAMINE BIOSYNTHESIS IN RAT PROSTATE - SUBSTRATE AND INHIBITOR PROPERTIES OF 7-DEAZA ANALOGS OF DECARBOXYLATED S-ADENOSYLMETHIONINE AND 5'-METHYLTHIOADENOSINE [J].

COWARD, JK ;

MOTOLA, NC ;

MOYER, JD .

JOURNAL OF MEDICINAL CHEMISTRY, 1977, 20 (04) :500-505

[4]

COWARD JK, 1979, DRUG ACTION DESIGN M, P13

[5] ALPHA-DEUTERIUM AND C-13 ISOTOPE EFFECTS FOR METHYL TRANSFER CATALYZED BY CATECHOL O-METHYLTRANSFERASE - SN2-LIKE TRANSITION-STATE [J].

HEGAZI, MF ;

BORCHARDT, RT ;

SCHOWEN, RL .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1979, 101 (15) :4359-4365

[6] STUDIES OF INHIBITION OF RAT SPERMIDINE SYNTHASE AND SPERMINE SYNTHASE [J].

HIBASAMI, H ;

BORCHARDT, RT ;

CHEN, SY ;

COWARD, JK ;

PEGG, AE .

BIOCHEMICAL JOURNAL, 1980, 187 (02) :419-428

[7] POLYAMINES IN RAPID GROWTH AND CANCER [J].

JANNE, J ;

POSO, H ;

RAINA, A .

BIOCHIMICA ET BIOPHYSICA ACTA, 1978, 473 (3-4) :241-293

[8]

JENCKS WP, 1975, ADV ENZYMOL RAMB, V43, P219

[9] ROLE OF BUFFERS IN A METHYLASE MODEL REACTION - GENERAL BASE CATALYSIS BY OXYANIONS VS NUCLEOPHILIC DEALKYLATION BY AMINES [J].

KNIPE, JO ;

COWARD, JK .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1979, 101 (15) :4339-4348

[10] ALPHA-DEUTERIUM ISOTOPE EFFECTS AND TRANSITION-STATE STRUCTURE IN AN INTRA-MOLECULAR MODEL SYSTEM FOR METHYL-TRANSFER ENZYMES [J].

MIHEL, I ;

KNIPE, JO ;

COWARD, JK ;

SCHOWEN, RL .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1979, 101 (15) :4349-4351

← 1 2 →