UTILIZATION OF OPERATIONAL SCHEMES FOR ANALOG SYNTHESIS IN DRUG DESIGN

被引：259

作者：

TOPLISS, JG

机构：

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1972年 / 15卷 / 10期

关键词：

D O I：

10.1021/jm00280a002

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

引用

收藏

页码：1006 / &

相关论文

共 17 条

[1] SYNTHESIS AND ANTIINFLAMMATORY ACTIVITY OF SOME ARYLTETRAZOLYLALKANOIC ACIDS
BUCKLER, RT
HAYAO, S
LORENZET.OJ
SANCILIO, LF
HARTZLER, HE
STRYCKER, WG
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1970, 13 (04) : 725 - &
[2] INTERDEPENDENCE BETWEEN PHYSICAL PARAMETERS AND SELECTION OF SUBSTITUENT GROUPS FOR CORRELATION STUDIES
CRAIG, PN
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1971, 14 (08) : 680 - &
[3] NEW SUBSTITUENT CONSTANT PI DERIVED FROM PARTITION COEFFICIENTS
FUJITA, T
HANSCH, C
IWASA, J
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1964, 86 (23) : 5175 - &
[4] INHIBITION OF MONOAMINE OXIDASE BY N-(PHENOXYETHYL)CYCLOPROPYLAMINES . CORRELATION OF INHIBITION WITH A HAMMET CONSTANTS AND PARTITION COEFFICIENTS
FULLER, RW
MARSH, MM
MILLS, J
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1968, 11 (02) : 397 - &
[5] RHO-SIGMA-PI ANALYSIS . METHOD FOR CORRELATION OF BIOLOGICAL ACTIVITY + CHEMICAL STRUCTURE
HANSCH, C
FUJITA, T
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1964, 86 (08) : 1616 - &
[6] ALPHA-CHYMOTRYPSIN - A CASE STUDY OF SUBSTITUENT CONSTANTS AND REGRESSION ANALYSIS IN ENZYMIC STRUCTURE-ACTIVITY RELATIONSHIPS
HANSCH, C
COATS, E
[J]. JOURNAL OF PHARMACEUTICAL SCIENCES, 1970, 59 (06) : 731 - &
[7] Hansch C., 1971, DRUG DESIGN, V11, P271
[8] Hine J., 1962, PHYSICAL ORGANIC CHE, P87
[9] SUBSTITUENT CONSTANTS FOR ALIPHATIC FUNCTIONS OBTAINED FROM PARTITION COEFFICIENTS
IWASA, J
FUJITA, T
HANSCH, C
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1965, 8 (02) : 150 - &
[10] A REEXAMINATION OF THE HAMMETT EQUATION
JAFFE, HH
[J]. CHEMICAL REVIEWS, 1953, 53 (02) : 191 - 261