PANCREASTATIN DECREASES PLASMA EPINEPHRINE LEVELS IN SURGICAL STRESS IN THE RAT

被引：18

作者：

SANCHEZMARGALET, V ^{[1
]}

GOBERNA, R ^{[1
]}

机构：

[1] UNIV SEVILLA,HOSP VIRGEN MACARENA,FAC MED,DEPT BIOQUIM MED & BIOL MOLEC,AVDA SANCHEZ PIZJUAN 4,E-41009 SEVILLE,SPAIN

来源：

PEPTIDES | 1993年 / 14卷 / 04期

关键词：

PANCREASTATIN; CHROMOGRANIN-A; CATECHOLAMINES; RAT; SURGICAL STRESS;

D O I：

10.1016/0196-9781(93)90116-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Pancreastatin is a novel peptide, isolated from porcine pancreatic extracts, that is known to be derived from chromogranin A. Since chromogranin A-derived peptides have been shown to control secretion from chromaffin cells, we studied the effect of mt pancreastatin, injected intravenously via portal vein, on plasma catecholamine levels in the anesthetized, laparotomized rat. Rat pancreastatin reversibly decreased plasma epinephrine levels, in a dose-dependent manner, without modifying plasma norepinephrine and dopamine levels. These findings suggest that pancreastatin, released from the gastroenteropancreatic system or derived from chromogranin A, may have a role controlling secretion from the adrenal medulla in surgical stress.

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页码：797 / 799

页数：3

相关论文

共 22 条

[1] PANCREASTATIN INHIBITS INSULIN-SECRETION AND STIMULATES GLUCAGON-SECRETION IN MICE [J].

AHREN, B ;

LINDSKOG, S ;

TATEMOTO, K ;

EFENDIC, S .

DIABETES, 1988, 37 (03) :281-285

[2] PANCREASTATIN DISTRIBUTION AND PLASMA-LEVELS IN THE PIG [J].

BRETHERTONWATT, D ;

GHATEI, MA ;

BISHOP, AE ;

FACER, P ;

FAHEY, M ;

HEDGES, M ;

WILLIAMS, G ;

VALENTINO, KL ;

TATEMOTO, K ;

ROTH, K ;

POLAK, JM ;

BLOOM, SR .

PEPTIDES, 1988, 9 (05) :1005-1014

[3] PANCREASTATIN AND ISLET HORMONE-RELEASE [J].

EFENDIC, S ;

TATEMOTO, K ;

MUTT, V ;

QUAN, C ;

CHANG, D ;

OSTENSON, CG .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (20) :7257-7260

[4] PEPTIDE FUNCTION - IS CHROMOGRANIN A PROHORMONE [J].

EIDEN, LE .

NATURE, 1987, 325 (6102) :301-301

[5] PANCREASTATIN, A PRESUMED PRODUCT OF CHROMOGRANIN-A (SECRETORY PROTEIN-I) PROCESSING, INHIBITS SECRETION FROM PORCINE PARATHYROID CELLS IN CULTURE [J].

FASCIOTTO, BH ;

GORR, SU ;

DEFRANCO, DJ ;

LEVINE, MA ;

COHN, DV .

ENDOCRINOLOGY, 1989, 125 (03) :1617-1622

[6] EFFECT OF PANCREASTATIN ON PANCREATIC ENDOCRINE FUNCTION IN THE CONSCIOUS RAT [J].

FUNAKOSHI, A ;

MIYASAKA, K ;

KITANI, K ;

TATEMOTO, K .

REGULATORY PEPTIDES, 1989, 24 (03) :225-231

[7] CHROMOSTATIN, A 20-AMINO ACID PEPTIDE DERIVED FROM CHROMOGRANIN-A, INHIBITS CHROMAFFIN CELL SECRETION [J].

GALINDO, E ;

RILL, A ;

BADER, MF ;

AUNIS, D .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (04) :1426-1430

[8]

GALINDO E, 1992, J BIOL CHEM, V267, P407

[9] VALIDITY AND RELIABILITY OF LIQUID-CHROMATOGRAPHY WITH ELECTROCHEMICAL DETECTION FOR MEASURING PLASMA-LEVELS OF NOREPINEPHRINE AND EPINEPHRINE IN MAN [J].

GOLDSTEIN, DS ;

FEUERSTEIN, G ;

IZZO, JL ;

KOPIN, IJ ;

KEISER, HR .

LIFE SCIENCES, 1981, 28 (05) :467-475

[10] INTRACRANIAL MICROINFUSION OF PANCREASTATIN ELEVATES BLOOD-GLUCOSE, FREE FATTY-ACIDS, AND CORTICOSTERONE IN RATS [J].

GUNION, MW ;

ROSENTHAL, MJ ;

TATEMOTO, K ;

MORLEY, JE .

BRAIN RESEARCH, 1989, 485 (02) :251-257