HYBRID HEPATITIS-B VIRUS NUCLEOCAPSID BEARING AN IMMUNODOMINANT REGION FROM HEPATITIS-B VIRUS SURFACE-ANTIGEN

被引：52

作者：

BORISOVA, G

ARYA, B

DISLERS, A

BORSCHUKOVA, O

TSIBINOGIN, V

SKRASTINA, D

ELDAROV, MA

PUMPENS, P

SKRYABIN, KG

GRENS, E

机构：

[1] LATVIAN ACAD SCI,INST MOLEC BIOL,53 KRUSTPILS ST,RIGA 1065,LATVIA

[2] UNIV LATVIA,RIGA 1065,LATVIA

[3] GRINDEX,RIGA 1065,LATVIA

[4] RUSSIAN ACAD SCI,CTR BIOENGN,MOSCOW 117984,RUSSIA

来源：

JOURNAL OF VIROLOGY | 1993年 / 67卷 / 06期

关键词：

D O I：

10.1128/JVI.67.6.3696-3701.1993

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

A hepatitis B core antigen (HBcAg) gene bearing the 39-amino-acid-long domain A of hepatitis B surface antigen (HBsAg) within the HBcAg immunodominant loop has been constructed and expressed in Escherichia coli. Chimeric capsids demonstrated HBs but not HBc antigenicity and elicited in mice B-cell and T-cell responses against native HBcAg and HBsAg.

引用

页码：3696 / 3701

页数：6

共 27 条

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