DELETION OF A COMMON REGION ON THE LONG ARM OF CHROMOSOME-6 IN ACUTE LYMPHOBLASTIC-LEUKEMIA

被引:36
作者
MENASCE, LP
ORPHANOS, V
SANTIBANEZKOREF, M
BOYLE, JM
HARRISON, CJ
机构
[1] PATERSON INST CANC RES,CANC RES CAMPAIGN,DEPT CANC GENET,MANCHESTER M20 9BX,LANCS,ENGLAND
[2] CHRISTIE CRC RES CTR,NW REG CYTOGENET SERV ONCOL,MANCHESTER,ENGLAND
关键词
D O I
10.1002/gcc.2870100105
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
We have characterised a region of deletion on the long arm of chromosome 6(6q) in six cases of acute lymphoblastic leukaemia, by fluorescence in situ hybridisation, using a series of YAC clones which map to 6q. Conventional cytogenetic analysis of four of these cases had been interpreted as showing terminal deletions of 6q. We demonstrated by FISH that in all cases the deletions were interstitial. D6S246 (6q16.3) was the only marker which was missing in all six cases, indicating a common region of deletion between the markers M6P1 at 6q14-15 and FYN at 6q21. Our results suggest the presence of a tumour suppressor gene within this interval. (C) 1994 Wiley-Liss, Inc.
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页码:26 / 29
页数:4
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