UNUSUALLY STRONG BINDING OF CA2+ IONS BY THE NOVEL ANTIBIOTIC SQUALESTATIN-1

被引：3

作者：

BAL, W

DRAKE, AF

JEZOWSKABOJCZUK, M

KOZLOWSKI, H

PETTIT, LD

SADLER, PJ

机构：

[1] UNIV LONDON,BIRKBECK COLL,DEPT CHEM,GORDON HOUSE & CHRISTOPHER INGOLD LABS,LONDON WC1H 0PP,ENGLAND

[2] UNIV WROCLAW,INST CHEM,PL-50383 WROCLAW,POLAND

[3] UNIV LEEDS,SCH CHEM,LEEDS LS2 9JT,W YORKSHIRE,ENGLAND

来源：

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS | 1994年 / 05期

关键词：

D O I：

10.1039/c39940000555

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The squalestatins, inhibitors of squalene synthase and potent antimicrobial agents, have potential both as cholesterol-lowering drugs and as antibiotics; using potentiometry and circular dichroism, we show that squalestatin-1 has a much higher affinity for Ca2+ than citrate, and readily inserts into SDS micelles (a model membrane), processes which may be relevant to its mechanism of action.

引用

页码：555 / 556

页数：2

共 11 条

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