NEUROLOGICAL REACTIONS IN HIV-INFECTED PATIENTS TREATED WITH TRICHOSANTHIN

被引：18

作者：

GARCIA, PA

BREDESEN, DE

VINTERS, HV

VONEINSIEDEL, RG

WILLIAMS, RL

KAHN, JO

BYERS, VS

LEVIN, AS

WAITES, LA

MESSING, RO

机构：

[1] UNIV CALIF LOS ANGELES,DEPT NEUROL,LOS ANGELES,CA 90024

[2] UNIV CALIF LOS ANGELES,DEPT PATHOL,LOS ANGELES,CA 90024

[3] GENELABS INC,REDWOOD CITY,CA

[4] US FDA,OFF GENER DRUGS,ROCKVILLE,MD 20857

[5] SAN FRANCISCO GEN HOSP,DEPT MED,SAN FRANCISCO,CA 94110

[6] IMMUNOL INC,SAN FRANCISCO,CA

[7] UNIV NOTTINGHAM,NOTTINGHAM NG7 2RD,ENGLAND

来源：

NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY | 1993年 / 19卷 / 05期

关键词：

TRICHOSANTHIN; GLQ223(R); RIBOSOME-INACTIVATING PROTEINS; PROGRESSIVE DIFFUSE LEUKOENCEPHALOPATHY; ACQUIRED IMMUNODEFICIENCY SYNDROME (AIDS); HUMAN IMMUNODEFICIENCY VIRUS (HIV);

D O I：

10.1111/j.1365-2990.1993.tb00461.x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Trichosanthin is a ribosome-inactivating protein that is being studied as a possible treatment for patients infected with human immunodeficiency virus (HIV). We report the clinical and pathological features in two patients who experienced neurological reactions to trichosanthin. Both patients were neurologically asymptomatic prior to treatment but developed coma and multifocal neurological deficits after treatment. Neuropathological examination revealed regions of severe, multifocal necrosis with histio-cytic infiltrates. These reactions to trichosanthin may be mediated by soluble factors released by HIV-infected macrophages.

引用

页码：402 / 405

页数：4

共 9 条

[1] HIV-Associated Disease of the Nervous System: Review of Nomenclature and Proposal for Neuropathology-Based Terminology [J].

Budka, Herbert ;

Wiley, Clayton A. ;

Kleihues, Paul ;

Artigas, Juan ;

Asbury, Arthur K. ;

Cho, Eun-Sook ;

Cornblath, David R. ;

Dal Canto, Mauro C. ;

DeGirolami, Umberto ;

Dickson, Dennis ;

Epstein, Leon G. ;

Esiri, Margaret M. ;

Giangaspero, Felice ;

Gosztonyi, Georg ;

Gray, Francoise ;

Griffin, John W. ;

Henin, Dominique ;

Iwasaki, Yuzo ;

Janssen, Robert S. ;

Johnson, Richard T. ;

Lantos, Peter L. ;

Lyman, William D. ;

McArthur, Justin C. ;

Nagashima, Kazuo ;

Peress, Nancy ;

Petito, Carol K. ;

Price, Richard W. ;

Rhodes, Roy H. ;

Rosenblum, Marc ;

Said, Gerard ;

Scaravilli, Francesco ;

Sharer, Leroy R. ;

Vinters, Harry V. .

BRAIN PATHOLOGY, 1991, 1 (03) :143-152

[2] A PHASE-I/II STUDY OF TRICHOSANTHIN TREATMENT OF HIV DISEASE [J].

BYERS, VS ;

LEVIN, AS ;

WAITES, LA ;

STARRETT, BA ;

MAYER, RA ;

CLEGG, JA ;

PRICE, MR ;

ROBINS, RA ;

DELANEY, M ;

BALDWIN, RW .

AIDS, 1990, 4 (12) :1189-1196

[3] IMMUNOHISTOCHEMICAL IDENTIFICATION OF HTLV-III ANTIGEN IN BRAINS OF PATIENTS WITH AIDS [J].

GABUZDA, DH ;

HO, DD ;

DELAMONTE, SM ;

HIRSCH, MS ;

ROTA, TR ;

SOBEL, RA .

ANNALS OF NEUROLOGY, 1986, 20 (03) :289-295

[4] SECRETION OF NEUROTOXINS BY MONONUCLEAR PHAGOCYTES INFECTED WITH HIV-1 [J].

GIULIAN, D ;

VACA, K ;

NOONAN, CA .

SCIENCE, 1990, 250 (4987) :1593-1596

[5] THE SAFETY AND PHARMACOKINETICS OF GLQ223 IN SUBJECTS WITH AIDS AND AIDS-RELATED COMPLEX - A PHASE-I STUDY [J].

KAHN, JO ;

KAPLAN, LD ;

GAMBERTOGLIO, JG ;

BREDESEN, D ;

ARRI, CJ ;

TURIN, L ;

KIBORT, T ;

WILLIAMS, RL ;

LIFSON, JD ;

VOLBERDING, PA .

AIDS, 1990, 4 (12) :1197-1204

[6] PROGRESSIVE DIFFUSE LEUKOENCEPHALOPATHY IN PATIENTS WITH ACQUIRED IMMUNE-DEFICIENCY SYNDROME (AIDS) [J].

KLEIHUES, P ;

LANG, W ;

BURGER, PC ;

BUDKA, H ;

VOGT, M ;

MAURER, R ;

LUTHY, R ;

SIEGENTHALER, W .

ACTA NEUROPATHOLOGICA, 1985, 68 (04) :333-339

[7] GLQ223 - AN INHIBITOR OF HUMAN IMMUNODEFICIENCY VIRUS-REPLICATION IN ACUTELY AND CHRONICALLY INFECTED-CELLS OF LYMPHOCYTE AND MONONUCLEAR PHAGOCYTE LINEAGE [J].

MCGRATH, MS ;

HWANG, KM ;

CALDWELL, SE ;

GASTON, I ;

LUK, KC ;

WU, P ;

NG, VL ;

CROWE, S ;

DANIELS, J ;

MARSH, J ;

DEINHART, T ;

LEKAS, PV ;

VENNARI, JC ;

YEUNG, HW ;

LIFSON, JD .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (08) :2844-2848

[8] HUMAN IMMUNODEFICIENCY VIRUS-INFECTED MACROPHAGES PRODUCE SOLUBLE FACTORS THAT CAUSE HISTOLOGICAL AND NEUROCHEMICAL ALTERATIONS IN CULTURED HUMAN BRAINS [J].

PULLIAM, L ;

HERNDIER, BG ;

TANG, NM ;

MCGRATH, MS .

JOURNAL OF CLINICAL INVESTIGATION, 1991, 87 (02) :503-512

[9]

PULLIAM L, 1991, AIDS, V5, P1237, DOI 10.1097/00002030-199110000-00013

← 1 →