NO REQUIREMENT OF REACTIVE OXYGEN INTERMEDIATES IN FAS-MEDIATED APOPTOSIS

被引：108

作者：

HUG, H ^{[1
]}

ENARI, M ^{[1
]}

NAGATA, S ^{[1
]}

机构：

[1] OSAKA BIOSCI INST,SUITA,OSAKA 565,JAPAN

来源：

FEBS LETTERS | 1994年 / 351卷 / 03期

关键词：

APOPTOSIS; FAS; SIGNAL TRANSDUCTION; REACTIVE OXYGEN INTERMEDIATE;

D O I：

10.1016/0014-5793(94)00852-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Fas is a cell surface molecule that mediates apoptosis, but the intracellular mechanisms leading to apoptosis are not well understood. It is known that diethylmaleate (DEM)-induced cell death can be blocked by substances with antioxidant activity. Here we have studied whether antioxidants have any effect on Fas-mediated apoptosis and show that they are not able to block Fas-mediated apoptosis. Therefore, it seems that reactive oxygen intermediate (ROI)-dependent and -independent mechanisms which lead to apoptosis do exist. Fas-mediated apoptosis probably proceeds via a ROI-independent pathway.

引用

页码：311 / 313

页数：3

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