THE EFFECT OF AGING ON PLATELET-FUNCTION AND FIBRINOLYTIC-ACTIVITY

被引:75
作者
GLEERUP, G
WINTHER, K
机构
[1] GLOSTRUP CTY HOSP,DEPT CARDIOL,COPENHAGEN,DENMARK
[2] GLOSTRUP CTY HOSP,DEPT CLIN CHEM,COPENHAGEN,DENMARK
关键词
D O I
10.1177/000331979504600810
中图分类号
R6 [外科学];
学科分类号
1002 ; 100210 ;
摘要
Twelve healthy young male volunteers, mean age twenty-five, range twenty-one to thirty years, and 12 healthy middle-aged male volunteers mean age fifty-eight, range forty-four to seventy-two years, were tested regarding platelet aggregation induced by adenosine diphosphate and fibrinolytic activity, estimated as euglobulin clot lysis time (ECLT), tissue plasminogen activator (t-PA), and the fast-acting inhibitor against t-PA normally referred to as (PAI-1). Platelet aggregation increased significantly in the middle-aged group as compared with the young, as shown by a decrease in ADP thresholds for irreversible aggregation (P < 0.01). In healthy young volunteers, vigorous cycling exercise by itself caused platelet aggregability to decrease (P < 0.05). Such changes were not observed in the elderly. Fibrinolytic activity decreased significantly in the middle-aged group as shown by a prolongation of the ECLT (P < 0.01) and PAI-1, although not significantly, increased by approximately 100%, whereas t-PA significantly increased in the middle-aged group (P < 0.01). The present results suggest that increasing age is associated with not only increased platelet aggregability but also decreased fibrinolytic activity.
引用
收藏
页码:715 / 718
页数:4
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