STRUCTURE OF MALHAMENSILIPIN-A, AN INHIBITOR OF PROTEIN-TYROSINE KINASE, FROM THE CULTURED CHRYSOPHYTE POTERIOOCHROMONAS-MALHAMENSIS

被引：49

作者：

CHEN, JL

PROTEAU, PJ

ROBERTS, MA

GERWICK, WH

SLATE, DL

LEE, RH

机构：

[1] OREGON STATE UNIV,COLL PHARM,CORVALLIS,OR 97331

[2] SYNTEX INC,RES,INST BIOCHEM & CELL BIOL,PALO ALTO,CA 94304

来源：

JOURNAL OF NATURAL PRODUCTS | 1994年 / 57卷 / 04期

关键词：

D O I：

10.1021/np50106a015

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

A new chlorosulfolipid, malhamensilipin A [1] was isolated from the cultured chrysophyte Poterioochromonas malhamensis. Malhamensilipin A was demonstrated to be a modest inhibitor of pp60(v-src) protein tyrosine kinase. The structure was determined by derailed spectral analysis to be a novel C-24 hexachloro lipid containing a vinyl sulfate ester (2,11,12,13,15,16-hexachloro-14-hydroxy-n-tetracos-1E-enol-1-sulfate).

引用

页码：524 / 527

页数：4

共 13 条

[1] EVALUATION OF NEW SESQUITERPENE QUINONES FROM 2 DYSIDEA SPONGE SPECIES AS INHIBITORS OF PROTEIN TYROSINE KINASE
ALVI, KA
DIAZ, MC
CREWS, P
SLATE, DL
LEE, RH
MORETTI, R
[J]. JOURNAL OF ORGANIC CHEMISTRY, 1992, 57 (24) : 6604 - 6607
[2] H-1 AND C-13 ASSIGNMENTS FROM SENSITIVITY-ENHANCED DETECTION OF HETERONUCLEAR MULTIPLE-BOND CONNECTIVITY BY 2D MULTIPLE QUANTUM NMR
BAX, A
SUMMERS, MF
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1986, 108 (08) : 2093 - 2094
[3] SENSITIVITY-ENHANCED TWO-DIMENSIONAL HETERONUCLEAR SHIFT CORRELATION NMR-SPECTROSCOPY
BAX, A
SUBRAMANIAN, S
[J]. JOURNAL OF MAGNETIC RESONANCE, 1986, 67 (03) : 565 - 569
[4] INVESTIGATION OF COMPLEX NETWORKS OF SPIN-SPIN COUPLING BY TWO-DIMENSIONAL NMR
BAX, A
FREEMAN, R
[J]. JOURNAL OF MAGNETIC RESONANCE, 1981, 44 (03) : 542 - 561
[5] Breitmaier E., 1990, CARBON 13 NMR SPECTR
[6] Haines T. H., 1973, LIPIDS BIOMEMBRANES, P197
[7] HALOGEN-CONTAINING AND SULFUR-CONTAINING LIPIDS OF OCHROMONAS
HAINES, TH
[J]. ANNUAL REVIEW OF MICROBIOLOGY, 1973, 27 : 403 - 411
[8] ANTIBIOTIC ACTIVITY OF CHRYSOPHYTE OCHROMONAS-MALHAMENSIS
HANSEN, JA
[J]. PHYSIOLOGIA PLANTARUM, 1973, 29 (02) : 234 - 238
[9] STARFISH SAPONINS .46. STEROIDAL GLYCOSIDES AND POLYHYDROXYSTEROIDS FROM THE STARFISH CULCITA-NOVAEGUINEAE
IORIZZI, M
MINALE, L
RICCIO, R
HIGA, T
TANAKA, J
[J]. JOURNAL OF NATURAL PRODUCTS, 1991, 54 (05): : 1254 - 1264
[10] MARINE SPONGE POLYKETIDE INHIBITORS OF PROTEIN TYROSINE KINASE
LEE, RH
SLATE, DL
MORETTI, R
ALVI, KA
CREWS, P
[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1992, 184 (02) : 765 - 772

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