CHROMATOGRAPHIC STUDY OF LOCAL-ANESTHETICS - BASIC ESTERS OF SUBSTITUTED CARBANILIC ACIDS .2. RELATIONSHIP BETWEEN CHROMATOGRAPHIC VALUES, OTHER PHYSICOCHEMICAL PARAMETERS AND ACTIVITY

RM values and the increment ΔRM(CH2) have been calculated from the chromatographic values RF of a group of anaesthetics comprising an homologous series of basic esters of substituted carbanilic acids. A linear relationship is demonstrated between RM values from partition chromatography and the partition coefficient (log P) or the substitution constant π. The chromatographic parameter RM is also correlated with the pharmacological characteristic log U, the logarithm of the surface anaesthetic activity. © 1979.