PROGNOSTIC VALUE OF PARANASOPHARYNGEAL EXTENSION OF NASOPHARYNGEAL CARCINOMA ON LOCAL-CONTROL AND SHORT-TERM SURVIVAL

被引:69
作者
SHAM, JST
CHOY, D
机构
[1] Department of Radiotherapy and Oncology, Queen Mary Hospital
来源
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK | 1991年 / 13卷 / 04期
关键词
D O I
10.1002/hed.2880130406
中图分类号
R76 [耳鼻咽喉科学];
学科分类号
100213 ;
摘要
The local tumor control of 262 patients with nasopharyngeal carcinoma (NPC) at median follow-up of 27 months was studied with reference to the paranasopharyngeal and other aspects of extranasopharyngeal extension of tumor, as well as to other possible prognostic factors. Only cranial nerve palsy, oropharyngeal involvement, and paranasopharyngeal extension of tumor were found to be significant in a multivariate analysis using Cox model for factors influencing local tumor control. Other factors and other parameters of extransopharyngeal extension of tumor, namely, erosion of the base of skull, intracranial extension, and involvement of nasal fossa, were found not to be significant. The degree of paranasopharyngeal extension in each side was correlated with scales measuring extranasopharyngeal extension of tumor in other directions (p = 0.001). Although the T stage and the paranasopharyngeal extension were individually found to be well correlated with local tumor control, the prognostic value of paranasopharyngeal extension remained significant among subgroups of patients with T3 and T4 disease (p = 0.1044 and 0.0010, respectively).
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页码:298 / 310
页数:13
相关论文
共 46 条
[1]  
BATSAKIS JG, 1979, TUMORS HEAD NECK, P188
[2]   CLINICAL-SIGNIFICANCE OF CRANIAL NERVE DEFICIT IN THE THERAPY OF NASOPHARYNGEAL CARCINOMA [J].
CHEN, MS ;
LIN, FJ ;
TANG, SG ;
LEUNG, WM ;
LEUNG, W .
BRITISH JOURNAL OF RADIOLOGY, 1989, 62 (740) :739-743
[3]   REGIONAL STAGE-IV CARCINOMA OF THE NASOPHARYNX TREATED BY AGGRESSIVE RADIOTHERAPY [J].
COOPER, JS ;
DELROWE, J ;
NEWALL, J .
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 1983, 9 (11) :1737-1745
[4]  
COX DR, 1972, J R STAT SOC B, V34, P187
[5]  
DICKSON RI, 1981, LARYNGOSCOPE, V91, P333
[6]   DIAGNOSTIC AND PROGNOSTIC ROLES OF OPHTHALMONEUROLOGIC SIGNS AND SYMPTOMS IN MALIGNANT NASOPHARYNGEAL TUMORS [J].
GODTFRED.E ;
LEDERMAN, M .
AMERICAN JOURNAL OF OPHTHALMOLOGY, 1965, 59 (06) :1063-&
[7]  
GUSTAFSON RO, 1989, CANCER HEAD NECK, P495
[8]  
Ho J H, 1978, IARC Sci Publ, P99
[9]  
HO JHC, 1978, INT J RADIAT ONCOL, V4, P182
[10]  
Ho JHC, 1982, TREATMENT CANCER, P249