INHIBITORY EFFECT OF HUMAN CHORIONIC-GONADOTROPIN (HCG) ON HIV-1 TRANSMISSION FROM LYMPHOCYTES TO TROPHOBLASTS

被引：26

作者：

BOURINBAIAR, AS ^{[1
]}

NAGORNY, R ^{[1
]}

机构：

[1] POPULAT COUNCIL,CTR BIOMED RES,NEW YORK,NY 10021

来源：

FEBS LETTERS | 1992年 / 309卷 / 01期

关键词：

HCG; HIV; LYMPHOCYTE; TROPHOBLAST; PLACENTA;

D O I：

10.1016/0014-5793(92)80744-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

It has been demonstrated that human chorionic gonadotropin (hCG) inhibits HIV production in vitro, suggesting that this soluble placental glycoprotein can control viral replication and spread in vivo. hCG - the major product of fetal trophoblasts - was tested on an in vitro model consisting of choriocarcinoma-derived ENAMI trophoblasts exposed to HIV-infected MOLT-4 lymphocytes. The results show a U-shaped antiviral dose- effect and suggest that hCG may contribute to protection against intrauterine transmission of HIV-1.

引用

页码：82 / 84

页数：3

共 16 条

[1]

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[2]

BARTOCCI A, 1982, CELL IMMUNOL, V71, P326, DOI 10.1016/0008-8749(82)90266-0

[3] MODULATING EFFECT OF HUMAN CHORIONIC-GONADOTROPIN ON LYMPHOCYTE BLASTOGENESIS [J].