SPECTRAL CHARACTERIZATION OF RUTHENIUM(III) TRANSFERRIN

被引：31

作者：

KRATZ, F ^{[1
]}

MESSORI, L ^{[1
]}

机构：

[1] UNIV FLORENCE,DEPT CHEM,I-50121 FLORENCE,ITALY

来源：

JOURNAL OF INORGANIC BIOCHEMISTRY | 1993年 / 49卷 / 02期

关键词：

D O I：

10.1016/0162-0134(93)85017-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The interaction of ruthenium(III) with human serum transferrin has been investigated through UV/visible and CD spectroscopy. At physiological pH transferrin firmly binds two ruthenium(III) equivalents at the same sites of iron(III). Binding requires the presence of bicarbonate as synergistic anion. Metal uptake from ruthenium(III) nitrilotriacetate is complete within a few minutes; in contrast, uptake from ruthenium(III) chloride does not occur at a significant extent even over a period of days. The chemical properties of the obtained ruthenium/transferrin complex are described.

引用

页码：79 / 82

页数：4

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