MICROBIOLOGICAL REDUCTION OF KETO-SULFONES - APPLICATION IN A 3-STEP SYNTHESIS OF (S)-(+)-BETA-ANGELICA LACTONE

被引：59

作者：

ROBIN, S

HUET, F

FAUVE, A

VESCHAMBRE, H

机构：

[1] UNIV MAINE,FAC SCI,SYNTH ORGAN LAB,CNRS,URA 482,BP 535,F-72017 LE MANS,FRANCE

[2] UNIV PARIS 11,CARBOCYCLES LAB,CNRS,URA 478,F-91405 ORSAY,FRANCE

[3] UNIV CLERMONT FERRAND,CHIM ORGAN BIOL LAB,CNRS,URA 485,F-63177 CLERMONT FERRAND,FRANCE

来源：

TETRAHEDRON-ASYMMETRY | 1993年 / 4卷 / 02期

关键词：

D O I：

10.1016/S0957-4166(00)82344-7

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Microbiological reductions of several keto-sulfones led to the corresponding hydroxy-sulfones in moderate to high enantiomeric excess. A three-step synthesis of (S)-(+)-beta-angelica lactone from ethyl-4-oxo-3-(phenyl-sulfonyl)-pentanoate via the intermediate chiral alcohol is described.

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页码：239 / 246

页数：8

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