LOCAL-ADMINISTRATION OF EAA ANTAGONISTS BLOCKS LIGHT-INDUCED PHASE-SHIFTS AND C-FOS EXPRESSION IN HAMSTER SCN

被引:113
作者
REA, MA
BUCKLEY, B
LUTTON, LM
机构
来源
AMERICAN JOURNAL OF PHYSIOLOGY | 1993年 / 265卷 / 05期
关键词
SUPRACHIASMATIC NUCLEI; EXCITATORY AMINO ACIDS; CNQX; MK-801; CIRCADIAN RHYTHM;
D O I
10.1152/ajpregu.1993.265.5.R1191
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
Syrian hamsters were fitted with guide cannulas stereotaxically aimed at the suprachiasmatic nuclei (SCN) and housed in constant darkness in cages equipped with running wheels. Animals received 300-nl injections of either vehicle, CNQX, or MK-801 into the region of the SCN 5 min before a brief (10 min at 20 lx) light exposure. Local administration of either 1 mM CNQX or 1 mM MK-801 at circadian time (CT) 18 significantly inhibited light-induced phase advances (vehicle = 52 +/- 9 min; CNQX = 12 +/- 7 min; MK-801 = 12 +/- 5 min; P < 0.05 relative to vehicle + light group). The effects of both drugs were reversible and dose related. Injection of 1 mM MK-801 at CT13.5 resulted in a 71% inhibition of light-induced phase delays (vehicle = -51 +/- 6 min; MK-801 = -15 +/- 5 min; P < 0.05), while CNQX failed to significantly inhibit light-induced phase delays (-39 +/- 10 min). Local administration of either 1 mM CNQX or MK-801 into the SCN region reduced the number of Fos-immunoreactive cells relative to vehicle-injected controls by approximately 32 and 44%, respectively (vehicle = 951 +/- 79; CNQX = 643 +/- 135, P < 0.05; MK-801 = 533 +/- 143, P < 0.05). These results demonstrate that both N-methyl-D-aspartic acid (NMDA) and non-NMDA receptors located in the SCN region mediate light-induced phase shifts and Fos expression in the SCN.
引用
收藏
页码:R1191 / R1198
页数:8
相关论文
共 40 条
[1]   PHOTIC INDUCTION OF FOS PROTEIN IN THE SUPRACHIASMATIC NUCLEUS IS INHIBITED BY THE NMDA RECEPTOR ANTAGONIST MK-801 [J].
ABE, H ;
RUSAK, B ;
ROBERTSON, HA .
NEUROSCIENCE LETTERS, 1991, 127 (01) :9-12
[2]   NMDA AND NON-NMDA RECEPTOR ANTAGONISTS INHIBIT PHOTIC INDUCTION OF FOS PROTEIN IN THE HAMSTER SUPRACHIASMATIC NUCLEUS [J].
ABE, H ;
RUSAK, B ;
ROBERTSON, HA .
BRAIN RESEARCH BULLETIN, 1992, 28 (05) :831-835
[3]   AVIAN PANCREATIC-POLYPEPTIDE PHASE-SHIFTS HAMSTER CIRCADIAN-RHYTHMS WHEN MICROINJECTED INTO THE SUPRACHIASMATIC REGION [J].
ALBERS, HE ;
FERRIS, CF ;
LEEMAN, SE ;
GOLDMAN, BD .
SCIENCE, 1984, 223 (4638) :833-835
[4]   LIGHT REGULATES EXPRESSION OF A FOS-RELATED PROTEIN IN RAT SUPRACHIASMATIC NUCLEI [J].
ARONIN, N ;
SAGAR, SM ;
SHARP, FR ;
SCHWARTZ, WJ .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (15) :5959-5962
[5]   EFFECTS OF EXCITATORY AMINO-ACID RECEPTOR ANTAGONISTS AND AGONISTS ON SUPRACHIASMATIC NUCLEUS RESPONSES TO RETINOHYPOTHALAMIC TRACT VOLLEYS [J].
CAHILL, GM ;
MENAKER, M .
BRAIN RESEARCH, 1989, 479 (01) :76-82
[6]   VENTRAL LATERAL GENICULATE-NUCLEUS EFFERENTS TO THE RAT SUPRACHIASMATIC NUCLEUS EXHIBIT AVIAN PANCREATIC POLYPEPTIDE-LIKE IMMUNOREACTIVITY [J].
CARD, JP ;
MOORE, RY .
JOURNAL OF COMPARATIVE NEUROLOGY, 1982, 206 (04) :390-396
[7]   DO NMDA RECEPTORS MEDIATE THE EFFECTS OF LIGHT ON CIRCADIAN BEHAVIOR [J].
COLWELL, CS ;
RALPH, MR ;
MENAKER, M .
BRAIN RESEARCH, 1990, 523 (01) :117-120
[8]   NMDA AS WELL AS NON-NMDA RECEPTOR ANTAGONISTS CAN PREVENT THE PHASE-SHIFTING EFFECTS OF LIGHT ON THE CIRCADIAN SYSTEM OF THE GOLDEN-HAMSTER [J].
COLWELL, CS ;
MENAKER, M .
JOURNAL OF BIOLOGICAL RHYTHMS, 1992, 7 (02) :125-136
[9]  
CURRAN T, 1987, ONCOGENE, V2, P79
[10]   FUNCTIONAL-ANALYSIS OF CIRCADIAN PACEMAKERS IN NOCTURNAL RODENTS .2. VARIABILITY OF PHASE RESPONSE CURVES [J].
DAAN, S ;
PITTENDRIGH, CS .
JOURNAL OF COMPARATIVE PHYSIOLOGY, 1976, 106 (03) :253-266