EXPRESSION OF MESSENGER-RNA FOR 55-KDA AND 75-KDA TUMOR-NECROSIS-FACTOR (TNF) RECEPTORS IN MOUSE CEREBROVASCULAR ENDOTHELIUM - EFFECTS OF INTERLEUKIN-1-BETA, INTERFERON-GAMMA AND TNF-ALPHA ON CULTURED-CELLS

被引：38

作者：

BEBO, BF ^{[1
]}

LINTHICUM, DS ^{[1
]}

机构：

[1] TEXAS A&M UNIV,COLL VET MED,DEPT VET PATHOBIOL,COLLEGE STN,TX 77843

来源：

JOURNAL OF NEUROIMMUNOLOGY | 1995年 / 62卷 / 02期

关键词：

ENDOTHELIAL CELLS; RECEPTOR; TUMOR NECROSIS FACTOR; MOUSE; CEREBROVASCULAR;

D O I：

10.1016/0165-5728(95)00113-5

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The interactions between tumor necrosis factor-alpha (TNF-alpha) and its receptors have been implicated to play an important role in the pathogenesis of experimental autoimmune encephalomyelitis (EAE). The effects of cytokines on the steady stare levels of TNF receptor (TNFr) mRNA in cerebrovascular endothelial cells (CVE) cultured from EAE-susceptible (SJL/J) and EAE-resistant (BALB/c) mice were examined. Interferon-gamma and interleukin-1 beta up-regulated the levels of both the 55-kDa and 75-kDa TNFr mRNA, while TNF-alpha had no effect. No differences were observed in cytokine-induced TNFr mRNA levels between BALB/c and SJL/J CVE that might explain differences in EAE susceptibility.

引用

页码：161 / 167

页数：7

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