PHARMACOLOGIC EFFECTS IN MAN OF A POTENT, LONG-ACTING DOPAMINE RECEPTOR AGONIST

被引：90

作者：

LEMBERGER, L

CRABTREE, RE

机构：

[1] INDIANA UNIV,SCH MED,DEPT PHARMACOL,INDIANAPOLIS,IN 46202

[2] INDIANA UNIV,SCH MED,DEPT MED,INDIANAPOLIS,IN 46202

[3] INDIANA UNIV,SCH MED,DEPT PSYCHIAT,INDIANAPOLIS,IN 46202

来源：

SCIENCE | 1979年 / 205卷 / 4411期

关键词：

D O I：

10.1126/science.382359

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Single-dose administration of pergolide mesylate (100 to 400 micrograms) results in a dose-related inhibition of prolactin secretion which persists for more than 24 hours. During multiple-dose administration of pergolide, plasma prolactin concentrations remain markedly reduced (greater than 80 percent) and gradually return to control levels several days after drug administration is discontinued. Copyright © 1979 AAAS.

引用

页码：1151 / 1153

页数：3

共 16 条

[1] GALACTORRHEA - SUCCESSFUL TREATMENT WITH REDUCTION OF PLASMA PROLACTIN LEVELS BY BROM-ERGOCRYPTINE
BESSER, GM
MCNEILLY, AS
EDWARDS, CRW
PARKE, L
FORSYTH, IA
[J]. BRITISH MEDICAL JOURNAL, 1972, 3 (5828) : 669 - &
[2] BROMOCRIPTINE IN PARKINSONISM
CALNE, DB
TEYCHENNE, PF
CLAVERIA, LE
EASTMAN, R
GREENACRE, JK
PETRIE, A
[J]. BMJ-BRITISH MEDICAL JOURNAL, 1974, 4 (5942): : 442 - 444
[3] EFFECT OF LERGOTRILE ON GALACTORRHEA AND GONADOTROPIN-SECRETION
CLEARY, RE
CRABTREE, R
LEMBERGER, L
[J]. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1975, 40 (05) : 830 - 833
[4] FRANTZ AG, 1978, FED PROC, V37, P2192
[5] FULLER RW, LIFE SCI
[6] KLAWANS HL, 1977, NEUROLOGY, V27, P390
[7] GALACTORRHEA - STUDY OF 235 CASES, INCLUDING 48 WITH PITUITARY TUMORS
KLEINBERG, DL
NOEL, GL
FRANTZ, AG
[J]. NEW ENGLAND JOURNAL OF MEDICINE, 1977, 296 (11) : 589 - 600
[8] LEMBERGER L, 1978, FED PROC, V37, P2176
[9] INHIBITORY EFFECT OF AN ERGOLINE DERIVATIVE (LERGOTRILE, COMPOUND 83636) ON PROLACTIN SECRETION IN MAN
LEMBERGER, L
CRABTREE, R
CLEMENS, J
DYKE, RW
WOODBURN, RT
[J]. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1974, 39 (03) : 579 - 584
[10] STUDIES ON ANTIPARKINSONIAN EFFICACY OF LERGOTRILE
LIEBERMAN, A
MIYAMOTO, T
BATTISTA, AF
GOLDSTEIN, M
[J]. NEUROLOGY, 1975, 25 (05) : 459 - 462

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