SYNTHESIS AND APPLICATION OF THERMALLY REVERSIBLE HETEROGELS FOR DRUG DELIVERY

被引：214

作者：

DONG, LC ^{[1
]}

HOFFMAN, AS ^{[1
]}

机构：

[1] UNIV WASHINGTON,CTR BIOENGN,SEATTLE,WA 98195

来源：

JOURNAL OF CONTROLLED RELEASE | 1990年 / 13卷 / 01期

关键词：

controlled drug delivery; poly(Niso-propyl acryl-amide); stimuli-responsive hydrogels; thermally reversible hydrogels;

D O I：

10.1016/0168-3659(90)90071-Z

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A new heterogeneous, thermally reversible hydrogel has been synthesized by γ-irradiation of solutions of N-isopropylacrylamide (NIPAAm) and bis-vinyl-terminated polydimethylsiloxane (VTPDMS). The heterogeneous hydrogel exhibits the same lower critical solution temperature (LCST) as the homopolymer of NIPAAm. The gel prepared with a 50% NIPAAm and 50% VTPDMS solution shows a surprisingly fast rate of shrinking when heated through the LCST. The result of differential scanning calorimetry confirms the existence of a microdomain structure in the gel. The effect of irradiation dose and crosslink concentration on the resultant, calculated crosslink density has been studied. The gel swells to a great extent in either water or ethanol, permitting a high loading of either hydrophilic or hydrophobic drugs. Zero-order release of progesterone from the gel has been observed. © 1990.

引用

页码：21 / 31

页数：11

共 17 条

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[3] Dong, Hoffman, Proc. 13th. Ann. Meet. Soc Biomater, (1987)
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[10] Brandrup, Immergut, Polymer Handbook, pp. IV-342, (1975)

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