A MULTICENTER, OPEN, CLINICAL-TRIAL OF A NEW INTRAVENOUS FORMULATION OF FUSIDIC ACID IN SEVERE STAPHYLOCOCCAL INFECTIONS

被引:24
作者
PORTIER, H
机构
[1] Service des Maladies Infectieus, Dijon, Hôpital du Bocage, CHRU
关键词
D O I
10.1093/jac/25.suppl_B.39
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
A new intravenous formulation of fusidic acid, containing sodium fusidate, was used to treat 54 seriously ill patients. Forty-nine patients were infected with fusidic acid sensitive staphylococci. Fusidic acid was given with another antibiotic in 46 cases and alone in three instances. Thirty-three (70.2%) of the 47 cases analysed were cured. Five patients failed to respond and five patients died whilst receiving therapy. Superinfection was recorded in four cases. Adverse events, mainly comprising local intolerance at the infusion site or abnormal liver function tests, were recorded in 22 (407%) patients. Therapy was withdrawn because of side effects in only four (7.4%) cases. © 1990 The British Society for Antimicrobial Chemotherapy.
引用
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页码:39 / 44
页数:6
相关论文
共 6 条
  • [1] STAPHYLOCOCCAL BACTEREMIA, FUSIDIC ACID, AND JAUNDICE
    HUMBLE, MW
    EYKYN, SJ
    PHILLIPS, I
    [J]. BMJ-BRITISH MEDICAL JOURNAL, 1980, 280 (6230): : 1495 - 1498
  • [2] FUSIDIC ACID-INDUCED HYPERBILIRUBINEMIA
    KUTTY, KP
    NATH, IVS
    KOTHANDARAMAN, KR
    BARROWMAN, JA
    PERKINS, PG
    RA, MUP
    HUANG, SN
    [J]. DIGESTIVE DISEASES AND SCIENCES, 1987, 32 (08) : 933 - 938
  • [3] Menday A P, 1976, Curr Med Res Opin, V4, P132, DOI 10.1185/03007997609109293
  • [4] ADDITIVES TO INTRAVENOUS FLUIDS
    PARSONS, RL
    BEAVIS, JP
    PADDOCK, GM
    DAVID, JA
    TROUNCE, JR
    [J]. BRITISH MEDICAL JOURNAL, 1976, 2 (6046) : 1256 - 1256
  • [5] RODER BL, 1989, J ANTIMICROB CHEMOTH, V23, P347
  • [6] PHARMACOKINETICS OF SODIUM FUSIDATE AFTER SINGLE AND REPEATED INFUSIONS AND ORAL-ADMINISTRATION OF A NEW FORMULATION
    TABURET, AM
    GUIBERT, J
    KITZIS, MD
    SORENSEN, H
    ACAR, JF
    SINGLAS, E
    [J]. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1990, 25 : 23 - 31