DECARBOXYLATION OF 2-AMINOMALONIC ACID-CATALYZED BY SERINE HYDROXYMETHYLTRANSFERASE IS, IN FACT, A STEREOSPECIFIC PROCESS

被引：9

作者：

THOMAS, NR ^{[1
]}

ROSE, JE ^{[1
]}

GANI, D ^{[1
]}

机构：

[1] UNIV ST ANDREWS,DEPT CHEM,PURDIE BLDG,ST ANDREWS KY16 9ST,FIFE,SCOTLAND

来源：

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS | 1991年 / 14期

关键词：

D O I：

10.1039/c39910000908

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Contrary to previous reports, 2-aminomalonic acid is decarboxylated stereospecifically by serine hydroxymethyltransferase; the newly introduced hydrogen occupies the 2-pro-S position of the glycine product.

引用

页码：908 / 909

页数：2

共 11 条

[1] FERN L-METHIONINE DECARBOXYLASE - KINETICS AND MECHANISM OF DECARBOXYLATION AND ABORTIVE TRANSAMINATION
AKHTAR, M
STEVENSON, DE
GANI, D
[J]. BIOCHEMISTRY, 1990, 29 (33) : 7648 - 7660
[2] HIGHLY STEREOSPECIFIC SYNTHESIS OF (R)-[2-H-2(1)] AND (S)-[2-H-2(1)] GLYCINE
ARMAREGO, WLF
MILLOY, BA
PENDERGAST, W
[J]. JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1976, (20): : 2229 - 2237
[3] BLAKLEY RL, 1969, FRONT BIOL, V13, P190
[4] STEREOCHEMISTRY OF THE REARRANGEMENT OF 2-AMINOETHANOL BY ETHANOLAMINE AMMONIA-LYASE
GANI, D
WALLIS, OC
YOUNG, DW
[J]. EUROPEAN JOURNAL OF BIOCHEMISTRY, 1983, 136 (02): : 303 - 311
[5] GANI D, 1990, PYRIDOXAL DEPENDENT, V2, P213
[6] STEREOSPECIFIC DECARBOXYLATION OF SPECIFICALLY LABELED CARBOXYL-C-14 AMINOMALONIC ACIDS BY L-ASPARTATE BETA-DECARBOXYLASE
PALEKAR, AG
TATE, SS
MEISTER, A
[J]. BIOCHEMISTRY, 1971, 10 (11) : 2180 - &
[7] PALEKAR AG, 1973, J BIOL CHEM, V248, P1158
[8] SCHIRCH L, 1982, ADV ENZYMOL RAMB, V53, P83
[9] L-METHIONINE DECARBOXYLASE FROM DRYOPTERIS-FILIX-MAS - PURIFICATION, CHARACTERIZATION, SUBSTRATE-SPECIFICITY, ABORTIVE TRANSAMINATION OF THE COENZYME, AND STEREOCHEMICAL COURSES OF SUBSTRATE DECARBOXYLATION AND COENZYME TRANSAMINATION
STEVENSON, DE
AKHTAR, M
GANI, D
[J]. BIOCHEMISTRY, 1990, 29 (33) : 7631 - 7647
[10] SYNTHESIS OF (2R)-[1-C-13]-2-AMINO-2-METHYLMALONIC AND (2S)-[1-C-13]-2-AMINO-2-METHYLMALONIC ACID, PROBES FOR THE SERINE HYDROXYMETHYLTRANSFERASE REACTION - STEREOSPECIFIC DECARBOXYLATION OF THE 2-PRO-R CARBOXY GROUP WITH THE RETENTION OF CONFIGURATION
THOMAS, NR
SCHIRCH, V
GANI, D
[J]. JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1990, (05) : 400 - 402

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