THE BINDING OF NONMUSCLE CALDESMON FROM BRAIN TO MICROTUBULES - REGULATIONS BY CA2+-CALMODULIN AND CDC2 KINASE

被引：21

作者：

ISHIKAWA, R ^{[1
]}

KAGAMI, O ^{[1
]}

HAYASHI, C ^{[1
]}

KOHAMA, K ^{[1
]}

机构：

[1] GUNMA UNIV,SCH MED,DEPT PHARMACOL,MAEBASHI,GUNMA 371,JAPAN

来源：

FEBS LETTERS | 1992年 / 299卷 / 01期

关键词：

CALDESMON; ACTIN; MICROTUBULE; CALMODULIN; CDC2; KINASE;

D O I：

10.1016/0014-5793(92)80099-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Nonmuscle caldesmon from bovine brain bound to microtubules with a stoichiometry of five tubulin dimers to one molecule of caldesmon with values of K(a) 4.5 x 10(5) M-1. The binding of caldesmon to microtubules was inhibited in the presence of Ca2+ and calmodulin. The phosphorylation of caldesmon by cdc2 kinase also eliminated the microtubule-binding activity. These results suggest that caldesmon may play a physiological role in the functions of microtubules.

引用

页码：54 / 56

页数：3

共 21 条

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