CONCOMITANT INTAKE OF NORTRIPTYLINE AND CARBAMAZEPINE

被引：40

作者：

BROSEN, K ^{[1
]}

KRAGHSORENSEN, P ^{[1
]}

机构：

[1] ODENSE UNIV HOSP,DEPT PSYCHIAT,DK-5000 ODENSE,DENMARK

来源：

THERAPEUTIC DRUG MONITORING | 1993年 / 15卷 / 03期

关键词：

CARBAMAZEPINE; NORTRIPTYLINE; INDUCTION; THERAPEUTIC DRUG MONITORING;

D O I：

10.1097/00007691-199306000-00015

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

A 73-year-old woman with bipolar manic-depressive illness was treated with nortriptyline, 75 mg/day, for more than 2 years. At this dose her mean (+/-SD) serum nortriptyline concentration (SNT) was 355 +/- 49 nM (n = 13). Nevertheless, the patient again was depressed and was admitted to initiate prophylactic treatment with carbamazepine. During concomitant intake of 500-600 mg/day carbamazepine, the SNT decreased to 140 and 134 nM and the depression persisted. The nortriptyline dose was therefore increased to 150 mg/day; the mean SNT rose to 402 +/- 69 nM (n = 4) and the depression disappeared. This case shows that carbamazepine induces nortriptyline metabolism.

引用

页码：258 / 260

页数：3

共 15 条

[1] NORTRIPTYLINE AND ANTIPYRINE CLEARANCE IN RELATION TO DEBRISOQUINE HYDROXYLATION IN MAN [J].