A CLUSTER-ANALYSIS STUDY OF ACETYL-L-CARNITINE EFFECT ON NMDA RECEPTORS IN AGING

被引：21

作者：

CASTORINA, M ^{[1
]}

AMBROSINI, AM ^{[1
]}

GIULIANI, A ^{[1
]}

PACIFICI, L ^{[1
]}

RAMACCI, MT ^{[1
]}

ANGELUCCI, L ^{[1
]}

机构：

[1] UNIV ROMA LA SAPIENZA,SCH MED,INST PHARMACOL 2,I-00187 ROME,ITALY

来源：

EXPERIMENTAL GERONTOLOGY | 1993年 / 28卷 / 06期

关键词：

NMDA RECEPTORS; AGING; CLUSTER ANALYSIS; ACETYL-L-CARNITINE;

D O I：

10.1016/0531-5565(93)90042-C

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Aging is associated with a reduction in the maximum density of n-methyl-d-aspartate (NMDA)-sensitive glutamate binding sites in the hippocampus of Fischer 344 rats. This study was designed to investigate the effect of acetyl-l-carnitine (ALCAR) on NMDA receptors in the old rat (24 months) after chronic or single-dose treatments. The number of NMDA receptors was significantly decreased in the old rat hippocampus by 19.5% compared with the young rat. A six-month treatment with ALCAR in the old rat attenuated the loss of NMDA binding sites in the hippocampus. A single-dose treatment with ALCAR in the old rat increased the B(max) value by 35%, while no change was observed in the young group. We conclude that ALCAR can exert two actions: a trophic/neuro-preserving one when chronically administered during aging, and a stimulatory one when given at a single dose in the aged rat.

引用

页码：537 / 548

页数：12

共 42 条

[1] REDUCED LIPOFUSCIN ACCUMULATION IN SENESCENT RAT-BRAIN BY LONG-TERM ACETYL-L-CARNITINE TREATMENT [J].

AMENTA, F ;

FERRANTE, F ;

LUCREZIOTTI, R ;

RICCI, A ;

RAMACCI, MT .

ARCHIVES OF GERONTOLOGY AND GERIATRICS, 1989, 9 (02) :147-153

[2] NERVE GROWTH-FACTOR BINDING IN AGED RAT CENTRAL NERVOUS-SYSTEM - EFFECT OF ACETYL-L-CARNITINE [J].

ANGELUCCI, L ;

RAMACCI, MT ;

TAGLIALATELA, G ;

HULSEBOSCH, C ;

MORGAN, B ;

WERRBACHPEREZ, K ;

PEREZPOLO, R .

JOURNAL OF NEUROSCIENCE RESEARCH, 1988, 20 (04) :491-496

[3]

ANGELUCCI L, 1990, Society for Neuroscience Abstracts, V16, P28

[4]

ANGELUCCI L, 1988, P23

[5]

ANGELUCCI L, 1986, MODULATION CENTRAL P, P337

[6]

ANGELUCCI L, 1992, CHOLINERGIC BASIS AL, P134

[7]

BARNES CA, 1982, PROGR BRAIN RES MOL, P253

[8] AGE-RELATED-CHANGES IN PASSIVE-AVOIDANCE RETENTION - MODULATION WITH DIETARY CHOLINE [J].

BARTUS, RT ;

DEAN, RL ;

GOAS, JA ;

LIPPA, AS .

SCIENCE, 1980, 209 (4453) :301-303

[9] A NEW INSIGHT INTO CHEMICAL MUTAGENESIS BY MULTIVARIATE DATA-ANALYSIS [J].

BENIGNI, R ;

GIULIANI, A .

JOURNAL OF THEORETICAL BIOLOGY, 1986, 121 (04) :477-486

[10]

BRADFORD MM, 1976, ANAL BIOCHEM, V72, P248, DOI 10.1016/0003-2697(76)90527-3

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